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EC number: 200-756-3
CAS number: 71-55-6
of in vivo micronucleus test
No. of mice
Micronucleated NCEs/1000 NCEs
P value (vs control)
P Value (trend)
P value (trend)
NCE = normochromatic erythrocyte
Following 13 weeks dietary exposure to microencapsulated
1,1,1-trichloroethane, at doses between 5,000 and 80,000 ppm,
examination of peripheral blood revealed and equivocal elevation of
micronucleated NCE’s in male mice and a negative response was recorded
in female mice. 2000 normochromatic erythrocytes were exaimined
for each aniamal. The dose levels used were associated with a
decrease in body weight gain, supporting systemic exposure to the test
mice there was a statistically significant rise (dose-related trend) in
the number of micronucleated cells up to 40,000ppm. The
mean value at 80,000ppm was the same as the untreated control (0.80).
group mean values were significantly increased compared to the control
(dose-related trend only). The
current OECD guidelines sate that statistical significance should not be
the only determining factor for a positive result. The
biological significance of the findings (for example background data)
are not discussed in this paper. It
is therefore considered that the results give no clear evidence of
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