Registration Dossier

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
two-generation reproductive toxicity
Remarks:
based on test type (migrated information)
Adequacy of study:
other information

Data source

Reference
Title:
No information
Author:
HSDB online via STN

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1,1-trichloroethane
EC Number:
200-756-3
EC Name:
1,1,1-trichloroethane
Cas Number:
71-55-6
Molecular formula:
C2H3Cl3
IUPAC Name:
1,1,1-trichloroethane
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male/female

Administration / exposure

Doses / concentrations
Remarks:
Doses / Concentrations:
0, 0.58, 1.75, or 5.83 mg/l = 0, 100, 300 or 1000 mg/kg
Basis:

Results and discussion

Overall reproductive toxicity

Reproductive effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
No taste aversion evident. There appeared to be no
dose-dependent effects on fertility, gestation, viability or
lactation indices. Pup survival and weight gain were not
adversely affected. No significant lethal mutations or
teratogenic effects in either of the 2 generations tested.

Applicant's summary and conclusion