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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Fairly recent work with clear objectives, description and results (not all results and no individual results presented). None guideline study and not GLP, but well designed to meet its objectives.

Data source

Reference
Reference Type:
publication
Title:
Acute, short-term, and subchronic oral toxicity of 1,1,1-trichloroethane in rats
Author:
BRUCKNER-JV; KYLE-GM; LUTHRA-R; ACOSTA-D; METHA-SM; SETHURAMAN-S; MURALIDHARA-S
Year:
2001
Bibliographic source:
TOXICOL-SCI 60 363-372

Materials and methods

Principles of method if other than guideline:
Study designed to assess the endpoint of liver toxicity and metabolism induction. Measurements made 24 hours after administration
GLP compliance:
no
Test type:
other: Single dose with 24 hours observation

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Analytical grade 99 %+ purity obtained from Aldrich Chemical Co. Purity confirmed by gas chromatography.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals and environmental conditions:
Reverse light-dark conditions (light 2100 to 0900 hours), dose administered at start of active dark phase

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
Singel oral dose, total volume 1 ml
Doses:
0, 0.5, 1.0, 2.0 and 4 g/kg body weight
No. of animals per sex per dose:
Not specified, assumed 5
Control animals:
yes
Details on study design:
Euthansed after 24 hours and examination of blood and liver samples

Results and discussion

Mortality:
none
Clinical signs:
not reported
Body weight:
not reported
Gross pathology:
not reported
Other findings:
Histopathological examination and measurement of liver: body weight, serum enzymes, hepatic NPSH levels ad G-6-Phase activity did not reveal hepatocellular damage at any dosage level.

Applicant's summary and conclusion

Conclusions:
A single bolus administration of up to 4 g/kg body weight to the male rat was not associated with mortality or any indication of liver damage.
Executive summary:

In an acute study designed primarily to assess effects on the liver, a single bolus administration of up to 4 g/kg body weight to the male rat was not associated with mortality or any indication of liver damage. The animals were observed for 24 hours after administration.