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EC number: 200-756-3
CAS number: 71-55-6
In table 2 in the study the
results of the QSAR analysis on 4 species of bacteria, 3 species of
algae, one species of fungi, one species of protozoa, one species of
coelenterate, one species of mollusc, 4 species of arthropods, one
species of fish and 3 species of amphibians are reported (the table is
too large for reproduction here). Similarly in table 3 which details
QSARS for narcotic chemicals 2 species of bacteria, 3 species of
arthropods, 5 species of fish and 2 species of amphibians are reported
(the table is too large for reproduction here. The authors note that for
narcotic chemicals QSARS based on the reproduction of Daphnia and early
life stage toxicity to fish species are the most sensitive of those
investigated. In addition the authors note that the HC5 values
calculated have a very similar SE values ranging from -0.85 to 0.13.
ARC values calculated on the
basis of experimental evidence are shown in the table below.
Number of studies
48-hour/28 day mortality
0.2 +/- 0.13
/20 day reproduction
0.86 +/- 0.53
28 day mortality/and growth
0.52 +/- 0.14
'96 hour mortality/32 day growth
1.05 +/- 0.31
28 day growth/'96 hour mortality
0.96 +/- 0.37
18 - 20 day reproduction
0.29 +/- 0.09
'96 hour population growth
0.55 +/- 0.09
15 minutes luminescence
0.79 +/- 0.26
Based on the nineteen NOEC based
QSARS from the second table in the report 81 HC5 calculations were
conducted. The authors note that these values take the form of a
curvilinear function of the Kow similar in shape to the lower confidence
limits obtained through linear regression analysis of the mean
assessment factor. The lowest estimate of toxicity using QSARS for
D.magnia and P.promelas/B.rerio is approximately 10 with no variation of
note between the different extrapolation procedures used. Tests to
confirm these assumptions with respect to species sensitivity
demonstrated that the assumptions were correct. In addition it was shown
that calculated HC5 values for bioaccumulation and sediment were
dependent on Kow values i.e the HC5 values for narcotic materials in
sediment with an organic carbon content of 5% and biota with a lipid
content of 5% is constant at approximately 10xE-5 mol/kg. At low Kow
values the HC5 total is identical to the HC5 water with differences
between the two values becoming apparent at Log Kow >4.0.
QSAR estimates of toxicity of
narcotic chemicals for 19 species of bacteria, algae, fungi, protozoans,
colenterates, rotifers, molluscs, crustaceans, insects, fish and
amphibians we used to predict the no effect level (NELs) at the
ecosystem level by means of recently developed equilibrium extrapolation
methods. Equilibrium partitioning theory was used to derive NELs for
aquatic sediments and internal toxicant concentrations for aquatic
organisms. The report contains a simple table depicting NELs for
narcotic chemicals for water, sediment and residues in biota. These can
be predicted on the basis of only the octanol/water partition
coefficient and the molecular weight of the material of concern.
Calculations were carried out for 102 narcotic chemicals.
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