Registration Dossier
Registration Dossier
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EC number: 200-001-8 | CAS number: 50-00-0
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: Review
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Review published in peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Formaldehyde in China: Production, consumption, exposure levels, and health effects
- Author:
- Tang X., Bai Y., Duong A., Smith M.T., Li L., Zhang L.
- Year:
- 2 009
- Bibliographic source:
- Environ Int 35(8), 1210-1224
Materials and methods
- Type of study / information:
- Among other, a review on the health effects of the test substance
- Endpoint addressed:
- genetic toxicity
- Principles of method if other than guideline:
- Review of existing data. This review also included studies regarding hematology being reported in the Chinese language.
- GLP compliance:
- no
Test material
- Reference substance name:
- Formaldehyde
- EC Number:
- 200-001-8
- EC Name:
- Formaldehyde
- Cas Number:
- 50-00-0
- Molecular formula:
- CH2O
- IUPAC Name:
- formaldehyde
- Details on test material:
- - Name of test material (as cited in study report): formaldehyde
Constituent 1
Method
- Ethical approval:
- not applicable
- Details on study design:
- Review of existing data
- Exposure assessment:
- not specified
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Longterm exposure to the test substance can decrease the number of WBC and possibly lower platelet and hemoglobin counts.
- Executive summary:
The authors referenced several papers in Chinese language reporting changes in blood cell counts as a result of the test substance exposure. Eight studies have been conducted in China concerning hematological parameters in test substance-exposed humans and published mainly in Chinese journals. The majority of the studies show that longterm exposure can decrease the number of WBC and possibly lower platelet and hemoglobin counts.
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