Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
200-001-8
CAS no.:
50-00-0
Index number:
Molecular formula:
CH2O
SMILES:
C=O
InChI:
InChI=1S/CH2O/c1-2/h1H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
30
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP06) approved by the European Union, this substance is toxic if swallowed, is toxic in contact with skin, causes severe skin burns and eye damage, is toxic if inhaled, may cause cancer, is suspected of causing genetic defects and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is fatal if inhaled and causes serious eye damage.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is suspected of causing cancer.

Breakdown of all 6284 C&L notifications submitted to ECHA

Acute Tox. 3 H301 Harmonised Classification
Acute Tox. 3 H311 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Acute Tox. 3 H331 Harmonised Classification
Carc. 2 H351
Eye Dam. 1 H318
Muta. 2 H341 Harmonised Classification
Carc. 1B H350 Harmonised Classification
Acute Tox. 2 H330
Skin Sens. 1A H317
STOT SE 3 H335
- H221
Flam. Liq. 3 H226
Aquatic Chronic 2 H411
https://echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (33.59% of REACH registrations).
  • M
Suspected to be Mutagenic (Harmonised C&L).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (66.79% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 38 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
This substance is approved for use as a Biocidal Active Substance
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is approved for use as a biocide in the EEA and/or Switzerland, for: disinfection, veterinary hygiene.

This substance is being reviewed for use as a biocide in the EEA and/or Switzerland, for: embalming or taxidermy.

This substance is used in the following products: adhesives and sealants, biocides (e.g. disinfectants, pest control products), coating products, fillers, putties, plasters, modelling clay, fuels, inks and toners, polishes and waxes, polymers, washing & cleaning products and cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, calendering operations, industrial spraying, transfer of substance into small containers, roller or brushing applications, treatment of articles by dipping and pouring, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release.

This substance can be found in products with material based on: paper used for large surface area articles (e.g. construction and building materials for insulation panels, wall papers), paper used for furniture & furnishings, fabrics, textiles and apparel, wood used for large surface area articles (e.g. construction and building materials for floors, claddings), wood used for furniture & furnishings and wood.

This substance is used in the following products: adhesives and sealants, coating products, laboratory chemicals and polymers.

This substance is used in the following areas: health services, agriculture, forestry and fishing, municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and scientific research and development. This substance is used for the manufacture of: electrical, electronic and optical equipment and machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, laboratory work, roller or brushing applications, non-industrial spraying and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: adhesives and sealants, polymers and laboratory chemicals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed processes with no likelihood of exposure and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, formulation in materials and in the production of articles.

This substance is used in the following products: adhesives and sealants. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals, plastic products, pulp, paper and paper products and textile, leather or fur.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed processes with no likelihood of exposure and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: in the production of articles, as processing aid, formulation of mixtures and formulation in materials.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures, formulation in materials, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Allnex Belgium NV/SA (OR7), Anderlechtstraat 33 1620 Drogenbos Belgium Belgium
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • Avellis Synco Leather GmbH, Daimlerring 11 65205 Wiesbaden Germany
  • BILTREC, S.A., Atlantida, 21 1º2º 08930 Sant Adria del Besos Barcelona Spain
  • C.S.B. GmbH, Düsseldorfer Str. 113 47809 Krefeld Germany
  • CAPA N.V., Leiebos 21, Bus 84 2170 Merksem Belgium
  • ChampionX Europe B.V., Oude Rhijnhofweg 17 NL-2342BB Oegstgeest Oegstgeest Netherlands
  • ChAR Consultancy EOOD, Kırdjali bulvard Bulgaria 37, blok 51 6600 Kırdjali Kırdjali Bulgaria
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Covestro Deutschland AG OR JP_000145, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Procurement Services GmbH & Co. KG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • CS3 GmbH, Grauertstrasse 12 81545 München Germany
  • Farbchemie Braun GmbH & Co.KG, Daimlerring 11 65205 Wiesbaden Germany
  • GIC International GmbH, Monschauer Str. 12 40459 Düsseldorf Germany
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden
  • Grupa Azoty S.A., ul. Kwiatkowskiego 8 33-101 Tarnow Poland
  • Harke Services GmbH-OR3, Xantener Str.1 45479 Mülheim an der Ruhr Germany
  • Hexion Botlek B.V., Chemiestraat 30 3197KB Botlek Rotterdam Netherlands
  • Hexion Germany GmbH, Varziner Straße 49 47138 Duisburg Germany
  • Intertek Deutschland GmbH_NAHL, Stangenstr.1 70771 Leinfelden-Echterdingen Germany
  • Kronochem Sebes SRL, 59 M.Kogalniceanu 515800 Sebes Romania
  • Luxcontrol S.A. (OR 57), 1, Avenue des Terres Rouges 4331 Esch sur Alzette Luxembourg
  • NWL FRANCE SERVICES, 122 avenue du Général Leclerc 92100 Boulogne Billancourt France France
  • Prefere Resins France, 10, Rue Comtesse F-62117 Brebieres France
  • Ramboll Deutschland GmbH, Werinherstraße 79 Gebäude 32a 81541 München Bayern Germany
  • REACH 2008 Ltd., j.k.Mladost-1,bl.32,entr.A, fl.5, ap.10 1784 Sofia Bulgaria Bulgaria
  • SI Group-Béthune S.A.S., 1111 Avenue George Washington Boite Postale 237 62404 Cedex Béthune France
  • Siemens Healthcare Diagnostics Products GmbH, Emil-von-Behring-Str. 76 35041 Marburg Germany
  • SNF S.A.S., ZAC de Milieux 42163 Andrézieux France
  • SNF SA, ZAC de Milieux 42163 Andrézieux France
  • Solenis Netherlands B.V., Pesetastraat 62 2991 XT Barendrecht Netherlands
  • Spetsinterproject Oy, Näkinkaari 1 M 02320 Espoo Finland
  • Texco Farben Produktionsgesellschaft mbH, Salegaster Chaussee 06803 Greppin Germany
  • Triade B.V., Dijkweg 159 2675 AD Honselersdijk Netherlands
  • UmEnA GmbH, Bachfeld 17 4211 Alberndorf Austria
  • [Confidential], [Confidential]
  • Caldic Chemie Produktie B.V., Westerlaan 1 3016 CK Rotterdam Netherlands
  • NEOCHIM PLC, East Industrial Zone, Himkombinatska Str. 6403 Dimitrovgrad Haskovo Bulgaria

Substance names and other identifiers

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Data not provided by the registrant

Melting/freezing point

Data not provided by the registrant

Boiling point

Data not provided by the registrant

Density

Data not provided by the registrant

Vapour pressure

Data not provided by the registrant

Partition coefficient

Data not provided by the registrant

Water solubility

Data not provided by the registrant

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Data not provided by the registrant

Flash point

Data not provided by the registrant

Auto flammability

Data not provided by the registrant

Flammability

Data not provided by the registrant

Explosiveness

Data not provided by the registrant

Oxidising

Data not provided by the registrant

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Data not provided by the registrant

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Data not provided by the registrant

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Data not provided by the registrant

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Data not provided by the registrant

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Data not provided by the registrant

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

Data not provided by the registrant

Short–term toxicity to fish

Data not provided by the registrant

Long–term toxicity to fish

Data not provided by the registrant

Short–term toxicity to aquatic invertebrates

Data not provided by the registrant

Long–term toxicity to aquatic invertebrates

Data not provided by the registrant

Toxicity to aquatic algae and cyanobacteria

Data not provided by the registrant

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Data not provided by the registrant

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Data not provided by the registrant

Toxicokinetics, metabolism, and distribution

Data not provided by the registrant

Acute toxicity

Data not provided by the registrant

Irritation / corrosion

Data not provided by the registrant

Sensitisation

Data not provided by the registrant

Repeated dose toxicity

Data not provided by the registrant

Genetic toxicity

Data not provided by the registrant

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Data not provided by the registrant

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant