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EC number: 200-001-8
CAS number: 50-00-0
The results obtained from the respective eye tests did not reveal any FA-induced irritant effects, up to the maximum concentrations which were 0.4 ppm with 0.8 ppm peak (4 times; 15 minutes each) and 0.7 ppm (over 4 hours), respectively. Conjunctival irritation: For conjunctival irritation, the authors observed numerically decreasing or constant post-exposure conjunctival redness levels rather than increased ones. This finding was not only restricted to the total collective of subjects, but also applied to the individual sensitivity groups, which exhibited a predominant decrease of conjunctival redness as well. Eye blinking frequency tended to decrease after FA exposure both in the total and the different sensitivity groups. It was only noticed a slight, albeit statistically not significant increase of eye blinking frequency in extremely hypersensitive volunteers after exposure to 0.5 ppm FA but not at 0.7 ppm FA. Tearfilm break-up time: Sensitivity-dependent effects on tearfilm break-up time by FA could not be identified. Nasal irritation: Nasal flow investigations revealed no uniform trend but an existence of a dose-effect relationship could not be derived. Therefore, it was concluded that any significant changes were not caused at all (or merely to a minor degree) by irritant effects FA has on the mucous membranes of the nose. The n-butanol threshold examinations conducted daily before and immediately after exposure did not indicate any significant concentration-dependent olfactory threshold changes. A dose-effect relationship was not apparent. There are no significant differences in the results of target parameters between hypo- and hypersensitive subjects
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