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EC number: 200-001-8
CAS number: 50-00-0
Table on mean values in % of applied dose for the distribution of 14C during the first 72 h after dermal application
Dose in mg
Distribution of radioactivity
Mean value ± SE
Number of animals per group
Air trapsUrineFaecesSkin (site of application)Remaining carcassTotal14C recoveredMean blood content #
0.37+-0.170.24+-0.100.20+-0.129.49+-3.90no datano data0.015+-0.0006
Mean of 3 animals (sex not given)
Presumably not occluded after application; aqueous solution; #: average of % dose in total blood volume over 1-24 h
The study is comparable with OECD guideline 417 with acceptable
restrictions (no data about toxic effects; no data are available on
remaining radioactivity in carcass or total recovered amount resulting
in limitation of the validity concerning absortion rate). Suitable for
comparison of selected parameters with other species (see other study
records of Jeffcoat et al.1983).
Each of 3 monkeys received dermal 2 mg 14-formaldehyde in 200 µL
solution.The skin of monkeys seems to be less permeable to aqueous
formaldehyde than that of rodents (see other study records of the
authors). Only 0.44% of applied radioactivity was excreted via urine and
faeces; 0.37% was accounted for as 14CO2 in the air traps and 9.5% of
the applied radioactivity was found at the site of application. No data
are available on remaining carcass or total recovered amount.
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