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EC number: 200-001-8
CAS number: 50-00-0
The single species Pseudomonas putida was exposed to the test item in a modified respiratory inhibition test. The NOEC was determined to be 30 mg/L.
was found to be harmful to the mixed bacterial inoculum, because it
inhibited oxygen consumption associated with peptone degradation.
methanol content of the test substance is not given. However, due to the
fact that the concentrations at which methanol shows effects to aquatic
organisms are several orders of magnitude lower than those expected for
formaldehyde, these do
not affect the results of the study.
study authors found probit analysis to be superior to the other two
methods with respect to curve fitting and confidence intervals.
The analysis by probit
test is considered as valid as the validity criteria given in OECD 209
(as adopted 1981) were met: a) the difference of the duplicate controls
was within a range of 15%; b) the sensitivity of the activated sludge
towards the reference substance was within the accepted range (EC50
between 5 and 30 mg/L).
Depending on local conditions and existing concentrations, disturbances in the biodegradation process of activated sludge are possible
In an activated sludge respiration inhibition test according to OECD 209 an EC50 of 19 mg/L was determined after 3h (Klecka et al., 1985). These findings are supported by another experimental study with mixed microorganism cultures from municipal wastewater (Tisler et al., 1997), no official guideline was followed. Nevertheless, the study is well documented and follows generally acceptable scientific principles. The inhibition of total respiration was measured and an EC50 of 34.1 mg/L after 120 h was determined. The EC10 (120 h) was 14.7 mg/L. These results are within the same range as in the guideline study (Klecka et al., 1985).
In addition, the NOEC in a single species test with Pseudomonas putida was determined in a modified respiratory inhibition test (Gericke, 1990). The NOEC was 30 mg/L. No exposure time is given but the result is similar to the previous mentioned results, so this value can be seen as plausible and supports the previous results.
In conclusion, based on the available experimental values the test item is harmful to microorganism and disturbance of degradation processes of activated sludge in sewage treatment plants is possible.
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