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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: Review
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Review published in peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Formaldehyde in China: Production, consumption, exposure levels, and health effects
Author:
Tang X., Bai Y., Duong A., Smith M.T., Li L., Zhang L.
Year:
2009
Bibliographic source:
Environ Int 35(8), 1210-1224

Materials and methods

Type of study / information:
Among other, a review on the health effects of the test substance
Endpoint addressed:
genetic toxicity
Principles of method if other than guideline:
Review of existing data. This review also included studies regarding hematology being reported in the Chinese language.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Formaldehyde
EC Number:
200-001-8
EC Name:
Formaldehyde
Cas Number:
50-00-0
Molecular formula:
CH2O
IUPAC Name:
formaldehyde
Details on test material:
- Name of test material (as cited in study report): formaldehyde

Method

Ethical approval:
not applicable
Details on study design:
Review of existing data
Exposure assessment:
not specified

Results and discussion

Applicant's summary and conclusion

Conclusions:
Longterm exposure to the test substance can decrease the number of WBC and possibly lower platelet and hemoglobin counts.
Executive summary:

The authors referenced several papers in Chinese language reporting changes in blood cell counts as a result of the test substance exposure. Eight studies have been conducted in China concerning hematological parameters in test substance-exposed humans and published mainly in Chinese journals. The majority of the studies show that longterm exposure can decrease the number of WBC and possibly lower platelet and hemoglobin counts.