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EC number: 200-001-8
CAS number: 50-00-0
Skin irritation in 2 rabbits
Exposure duration 20 h
24 h after initiation
Superficial Ne & B
48 h after initiation
72 h after initiation
Ne (leather like)
Ne (black, hardened)
Ne: necrosis; B: bleeding
In a reliable study comparable to OECD TG 404, the test substance was tested for its potential to cause acute dermal irritation or corrosion by a single topical application for 20 hours to the shaved skin of 2 White Vienna rabbits, using a patch of 2.5 cm x 2.5 cm soaked with 40 % formalin, covered with occlusive dressing. After removal of the patch the application area was washed off. Readings were performed 24, 48, 72 h and 6 and 8 days after application.
Beside edema and erythema superficial necrosis was obvious 24 h after initiation of exposure. In both rabbits full thickness necrosis were found the following days.
A solution of 40 % formalin induced full thickness necrosis in 2 rabbits after 20 h occlusive exposure.
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