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EC number: 200-001-8
CAS number: 50-00-0
Skin irritation in 2 rabbits
Exposure duration 20 h
24 h after initiation
Superficial Ne & B
48 h after initiation
72 h after initiation
Ne (leather like)
Ne (black, hardened)
Ne: necrosis; B: bleeding
Comparable to guideline study (BASF Test) with acceptable restrictions
(exposure period 20 h; occlusive dressing; application of a patch soaked
with ca. 1 mL formalin; partly limited documentation, no details about
the test substance).
Two White Vienna rabbits were exposed for 20 h under occlusive dressing
to a patch (2.5 x 2.5 cm²) soaked with 40% formalin. Readings were
performed 24, 48, 72 h and 6 and 8 days after application. Beside edema
and erythema superficial necrosis was obvious 24 h after initiation of
exposure. In both rabbits full thickness necrosis were found the
Conclusion: A solution of 40% formalin induced full thickness necrosis
in 2 rabbits after 20 h occlusive exposure.
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