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EC number: 200-001-8
CAS number: 50-00-0
A follow-up through December 2012 was conducted in the British (UK) cohort from six factories comprising 14,008 men in the period 1941–2012Mortality was compared with national death rates for England and Wales.
At 5 factories, all male employees were enrolled, while at the sixth (British Petroleum), where only a small proportion of the workforce had been exposed to formaldehyde, recruitment was limited to formaldehyde workers and a subset of men who had worked in other parts of the plant (2 for each exposed man).
The cohort was traced through the National Health Service Central Register (now the Health and Social Care Information Centre) and in some cases national insurance records, and was followed through December 31, 2012. For men who had died, the authors obtained the underlying and contributing causes of death, coded to the Ninth (deaths through the end of 2000) or Tenth (deaths since 2000) revision of the International Classification of Diseases. For those with registered cancers, the authors obtained information on the type of cancer and the date of registration.
Additionally, a nested case-control analyses of 115 men with upper airway cancer (including 1 nasopharyngeal cancer), 92 men with leukemia, and 45 men with myeloid leukemia was performed. ORs for these cancers were independent of the duration of the exposure
A total of 9,172 cohort members had exposures above the background level, including 3,991 who at some time were highly exposed. In the period, 7,378 men had died, 5,449 were still alive, and the other 1,181 had been lost to follow-up. Overall mortality in the cohort was significantly higher than expected from national rates (standardized mortality ratio (SMR) = 1.05, 95% confidence interval: 1.03, 1.08). The standardised mortality ratio [SMRs (95 % CI)] for all cancers [1.10 (1.06–1.15)], stomach [1.29 (1.11–1.49)], rectum [1.23 (1.01–1.49)], and for lung cancer [1.26 (1.17–1.35)] was significantly increased based on the national death rate for England and Wale. The nested case-control analyses of 115 men with upper airway cancer (including 1 nasopharyngeal cancer), 92 men with leukemia, and 45 men with myeloid leukemia indicated no elevations of risk in the highest exposure category (high exposure for ≥1 year). There was no excess mortality from nasopharyngeal cancer; the only death occurred in a man with low/moderate exposure (1.7 deaths expected for exposures above background).
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