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EC number: 200-001-8
CAS number: 50-00-0
effects on behaviour, appearance, motility and muscular co-ordination in
dogs observed for a more prolonged period.
meets generally accepted scientific standards but limited number of
parameters examined. Further deficiencies: No data about purity
of the test substance; only low dose tested without maternal toxicity;
some evaporation of formaldehyde prior to consumption presumed
(resulting in lower dose levels). Study limited to a restricted number
of parameters (e.g. data on visceral or skeletal alterations only in
stillborn pups or pups which died later in post natal observation
period, no data on maternal weight gain). No statistical analysis.
Beagle dogs (9-10 pregnant bitches per dose) were exposed from day 4
after mating up to day 56 to a diet containing formaldehyde at dose
levels of 0, 3.1, or 9.4 mg/kg bw/day. The dose levels (max. 9.4 mg/kg
bw) and concentrations (max. 0.037% in the diet) were relative low (no
local effects expected). No toxic effects were reported in the bitches
(but no data on body weight gain). External malformations were examined
immediately after birth and after 8 weeks. Autopsy was performed on
stillborn pups and those lost before weaning. Further parameters: total
pups at birth, total live pups at birth, total pups at weaning, mean
live (or total) pups per litter at birth and at weaning, mean litter
size, sex ratio, mean pup weight (measured daily after birth for 8
days). Concerning the investigated parameters no developmental toxicity
developmental effects in dogs exposed via the diet to doses up to 9.4
mg/kg bw/day but limited number of parameters examined.
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