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EC number: 200-001-8
CAS number: 50-00-0
In a reliable GLP conform study according to OECD TG 406, formaldehyde was tested for its potential to have a sensitizing effect with the help of the Guinea Pig Maximization Test based on the method of Magnusson and Kligman. Twenty females were induced by intradermal injection and topical application with 5 % formaldehyde solution, 10 female controls were shame treated. Challenge was performed with 2 or 4 % formaldehyde solution.
Controls gave valid results after both concentrations. In test animals 4 % formaldehyde solution resulted in positive reaction in all tested animals and 2 % formaldehyde solution in 80 % positive reactions in the first reading 48 hours after challenge application.
Under these test conditions and following the results described formaldehyde has a sensitizing effect on the skin of the guinea pig.
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