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EC number: 200-001-8
CAS number: 50-00-0
In a reliable study, in vivo, the eyes were exposed to small filter discs soaked with 0, 20, 100, 200 or 300 ppm of formaldehyde in water for 5 min. Eyes were washed with BSS. Gentamycin was applied to the eye two times daily. 1, 3, 7 and 10 days after exposure filter strips were introduced into the rabbit’s eye to measure moisture according to the Schirmer’s test. In vitro rabbit corneal cell preparations were exposed to aqueous solutions containing 5 - 600 ppm formaldehyde over 3 - 5 min and cell morphology, death and proliferation were determined as well as changes of mitochondria.
In vivo, tear production was increased at all exposure concentrations and observation times. In vitro, already 5 ppm induced damage to the corneal cells that became apparent only after prolonged observation period. Higher concentrations led to effects already after shorter periods.
These data suggest corrosive properties.
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