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EC number: 200-001-8
CAS number: 50-00-0
In a reliable GLP-conform study according to OECD TG 403, male and female Wistar rats were exposed to 463 ppm (analytical concentration) of formaldehyde as a vapor to determine the acute inhalation toxicity (single 4-hour exposure, whole body).
At 463 ppm all of five male and five female animals died. Lethality was observed on study day 1 or 2. Clinical signs of toxicity in animals comprised gasping, respiration sounds, breathing in stretched position, closed eyelid, red discharge and red encrusted nose, poor general condition, salivation, piloerection and yellow discolored fur. Findings were observed from hour 1 of exposure until the death of the animals. The mean body weights of the animals´surviving the exposure period decreased until death. During necropsy all animals showed dilated stomach, which were filled with gaseous content. Four males and four females additionally showed similar findings in the intestine. Moreover, two males showed effusion (clear fluid) in the thoracic cavity.
Under the current study condition, the LC50 was < 463 ppm (analytical concentration) in Wistar rats after 4 hour inhalation exposure to a vapor of formaldehyde.
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