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Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data obtained in an official monitoring study presented by German authorities

Data source

Reference Type:
The German Environmental Survey 1990/92 (GerES II): Sources of personal exposure to volatile organic compounds
Hoffmann K, Krause C, Seifert B, Ullrich D
Bibliographic source:
Journal of Exposure Analysis and Environmental Epidemiology 10, 115-125

Materials and methods

Type of study / information:
Personal inhalation exposure to organic volatile compounds at home
Endpoint addressed:
other: Inhalation exposure
Principles of method if other than guideline:
Exposure of the general public to volatile organic compounds was determined by using personal samplers and sampling over a period of one week.
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl benzoate
EC Number:
EC Name:
Methyl benzoate
Cas Number:
Molecular formula:
methyl benzoate


Ethical approval:
other: not required
Details on study design:
A random sample of 113 was drawn from the participants of the German Environmental Survey 1990/92. The selected subjects were instructed on how to use the sampler and then wore the sampler over a period of seven days. Sampling was conducted close to the breathing zone of the subjects. At the end of the sampling period, the sampler's collector surface was covered with the lid provided by the manufacturer for this purpose, the sampler was wrapped in aluminium foil and sent to the laboratory for analysis. Subjects were asked to fill in a specific questionnaire. The diffusive samplers were analysed by a gas chromatographic procedure according to the German VDI guideline.
Exposure assessment:

Results and discussion

The concentration of methyl benzoate was above the limit of quantification in 35 of 113 samples (31%). The geometric mean of inhalation exposure was 1.8 µg/m3 (confidence interval of 1.6 to 2.1 µg/m3). The 95 percentile of inhalation exposure was 7 µg/m3.

Applicant's summary and conclusion

Methyl benzoate was found in the air of 31% of homes. Subjects were exposed to a geometric mean of 1.8 µg/m3.