Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-259-7 | CAS number: 93-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 39.3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 12.5
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 491 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No inhalation study is available and NOAEC was derived by route to route extrapolation from the NOAEL. 8 h exposure time, extrapolation from 50% bioavailability oral to 100% bioavailability inhalation. Corrected inhalatory NOAEC = 557 mg/kg bw/day*(1/0.38 m3/kg/day)*(50%/100%)*(6.7 m3 (8h)/10 m3 (8h)) = 491 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- not required, starting point is NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- chronic study
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not for concentrations
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- default factor for worker
- AF for the quality of the whole database:
- 1
- Justification:
- not required
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 557 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- assumed that rat oral and dermal absorptions are equal to human oral and dermal absorption
- AF for dose response relationship:
- 1
- Justification:
- not required, starting point is NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- chronic study
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- allometric scaling factor rat-human
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining differences
- AF for intraspecies differences:
- 5
- Justification:
- default factor for worker
- AF for the quality of the whole database:
- 1
- Justification:
- not required
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- repeated dose toxicity
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The long-term inhalation DNEL for systemic effects is derived from the chronic oral toxicity study, where NOAEL is 557 mg/kg bw/day. Route-to-route (oral-inhalation) extrapolation was performed. The calculated DNEL is 39.3 mg/m3, applying the assessment factor of 12.5. Enzyme-driven hydrolysis of methyl benzoate in organisms releases methanol in equimolar amounts. The proposed DNEL for methyl benzoate of 39.3 mg/m3 is equivalent to a methanol dose of 9.2 mg/m3. According to the ECHA dissemination page, the DNEL for effects of long-term inhalation exposure to methanol is 260 mg/m3. Hence, the inhalation dose of methanol of 9.2 mg/m3 is clearly below this inhalation DNEL. It can be concluded that methanol is likely to have low contribution to the repeated dose inhalation toxicity of methyl benzoate. A detailed assessment of methanol exposure therefore is not required.
The long-term dermal DNEL for systemic effects is derived from the chronic oral toxicity study. For the route-to-route extrapolation it was assumed that oral and dermal absorption in the rat are equal to human oral and dermal absorption. The calculated DNEL is 11 mg/kg bw/day, applying the assessment factor of 50. Enzyme-driven hydrolysis of methyl benzoate in organisms releases methanol in equimolar amounts. The proposed DNEL for methyl benzoate of 11 mg/kg bw/day is equivalent to a methanol dose of 2.6 mg/kg bw/day. According to the ECHA dissemination page, the DNEL for effects of long-term dermal exposure to methanol is 40 mg/kg bw/day. Hence, the dermal dose of methanol of 2.6 mg/kg bw/day is clearly below this dermal DNEL. It can be concluded that methanol is likely to have low contribution to the repeated dose dermal toxicity of methyl benzoate. A detailed assessment of methanol exposure therefore is not required.
The long-term inhalation and dermal DNELs for local effects were not derived, since no local irritation potential was identified in skin irritation studies and only slight, transient effects on conjunctivae were observed.
The acute/short term inhalation DNEL for systemic effects was not required, since the substance is unlikely to exert significant acute toxicity via the inhalation route.
The acute/short term exposure dermal DNEL for systemic effects was not derived, since no hazard was identified for Methyl benzoate for dermal toxicity. It is anticipated that incidences of potential acute dermal exposure to the substance are covered with the DNEL for dermal long-term exposure of workers, i. e. 11 mg/kg bw/day. Enzyme-driven hydrolysis of methyl benzoate in organisms releases methanol in equimolar amounts. The proposed DNEL for methyl benzoate of 11 mg/kg bw/day is equivalent to a methanol dose of 2.6 mg/kg bw/day. According to the ECHA dissemination page, the DNEL for effects of short-term dermal exposure to methanol is 40 mg/kg bw/day. Hence, the dermal dose of methanol of 2.6 mg/kg bw/day is clearly below this dermal DNEL. It can be concluded that methanol is likely to have low contribution to the acute dermal toxicity of methyl benzoate. A detailed assessment of methanol exposure therefore is not required.
The acute/short term inhalation and dermal DNELs for local effects were not derived, since no local irritation potential was identified in skin irritation studies and only slight, transient effects on conjunctivae were observed.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.68 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 242 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No inhalation study is available and the NOAEC was derived by route to route extrapolation from the oral NOAEL. 24 h exposure time, extrapolation from 50% bioavailability oral to 100% bioavailability inhalation. Corrected inhalatory NOAEC = 557 mg/kg bw/day*(1/1.15 m3/kg/day)*(50%/100%) = 242 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- not required, starting point is NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- chronic study
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not for concentration
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default factor for general population
- AF for the quality of the whole database:
- 1
- Justification:
- not required
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.57 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 557 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- assumed that rat oral and dermal absorptions are equal to human oral and dermal absorption
- AF for dose response relationship:
- 1
- Justification:
- not required, starting point is NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- chronic study
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- allometric scaling factor rat-human
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default factor for general population
- AF for the quality of the whole database:
- 1
- Justification:
- not required
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.57 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 557 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- no route-to-route extrapolation performed
- AF for dose response relationship:
- 1
- Justification:
- not required, starting point is NOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- chronic study
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- allometric scaling factor rat-human
- AF for other interspecies differences:
- 2.5
- Justification:
- default factor for remaining differences
- AF for intraspecies differences:
- 10
- Justification:
- default factor for general population
- AF for the quality of the whole database:
- 1
- Justification:
- not required
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
- Most sensitive endpoint:
- acute toxicity
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The long-term inhalation DNEL for systemic effects is derived from the chronic oral toxicity study with a NOAEL of 557 mg/kg bw/day. Route-to-route (oral-inhalation) extrapolation was performed. The calculated DNEL is 9.68 mg/m3, applying the assessment factor of 25. Enzyme-driven hydrolysis of methyl benzoate in organisms releases methanol in equimolar amounts. The proposed DNEL for methyl benzoate of 9.68 mg/m3 is equivalent to a methanol dose of 2.2 mg/m3. According to the ECHA dissemination page, the DNEL for effects of long-term inhalation exposure to methanol is 50 mg/m3. Hence, the inhalation dose of methanol of 2.2 mg/m3 is clearly below this inhalation DNEL. It can be concluded that methanol is likely to have low contribution to the repeated dose inhalation toxicity of methyl benzoate. A detailed assessment of methanol exposure therefore is not required.
The long-term dermal DNEL for systemic effects is derived also from the chronic oral toxicity study. For the route-to-route (oral-dermal) extrapolation it was assumed that oral and dermal absorption in the rat are equal to human oral and dermal absorption. The calculated DNEL is 5.57 mg/kg bw/day, applying the assessment factor of 100. Enzyme-driven hydrolysis of methyl benzoate in organisms releases methanol in equimolar amounts. The proposed DNEL for methyl benzoate of 5.57 mg/kg bw/day is equivalent to a methanol dose of 1.3 mg/kg bw/day. According to the ECHA dissemination page, the DNEL for effects of long-term dermal exposure to methanol is 8 mg/kg bw/day. Hence, the dermal dose of methanol of 1.3 mg/kg bw/day is clearly below this dermal DNEL. It can be concluded that methanol is likely to have low contribution to the repeated dose dermal toxicity of methyl benzoate. A detailed assessment of methanol exposure therefore is not required.
The long-term oral DNEL for systemic effects is derived from the chronic oral toxicity study. No route-to-route extrapolation was performed. The calculated DNEL is 5.57 mg/kg bw/day, applying assessment factor of 100. Enzyme-driven hydrolysis of methyl benzoate in organisms releases methanol in equimolar amounts. The proposed DNEL for methyl benzoate of 5.57 mg/kg bw/day is equivalent to a methanol dose of 1.3 mg/kg bw/day. According to the ECHA dissemination page, the DNEL for effects of long-term oral exposure to methanol is 8 mg/kg bw/day. Hence, the oral dose of methanol of 1.3 mg/kg bw/day is clearly below this oral DNEL. It can be concluded that methanol is likely to have low contribution to the repeated dose oral toxicity of methyl benzoate. A detailed assessment of methanol exposure therefore is not required.
The long-term inhalation and dermal DNELs for local effects were not derived, since no local irritation potential was identified in skin irritation studies and only slight, transient effects on conjunctivae were observed. The compound is not classified for skin and eye irritation, therefore, no hazard was identified.
The acute/short term inhalation DNEL for systemic effects was not required, since the substance is unlikely to exert significant acute toxicity via the inhalation route. In addition, fragranced end-products meant for use by the general public contain low amounts of methyl benzoate, generally < 1%.
The acute/short term dermal DNEL for systemic effects was not derived, since methyl benzoate shows no acute dermal toxicity. It is anticipated that incidences of potential acute dermal exposure to the substance are covered with the DNEL for dermal long-term exposure of general population, i. e. 5.57 mg/kg bw/day. In addition, fragranced end-products meant for use by the general public contain low amounts of methyl benzoate, generally < 1%. Enzyme-driven hydrolysis of methyl benzoate in organisms releases methanol in equimolar amounts. The proposed DNEL for methyl benzoate of 5.57 mg/kg bw/day is equivalent to a methanol dose of 1.3 mg/kg bw/day. According to the ECHA dissemination page, the DNEL for effects of short-term dermal exposure to methanol is 8 mg/kg bw/day. Hence, the dermal dose of methanol of 1.3 mg/kg bw/day is clearly below this dermal DNEL. It can be concluded that methanol is likely to have low contribution to the acute dermal toxicity of methyl benzoate. A detailed assessment of methanol exposure therefore is not required.
The acute/short term oral DNEL for system effects was not derived, since methyl benzoate exhibits only low acute oral toxicity. It is anticipated that incidences of potential acute oral exposure to the substance are covered with the DNEL for oral long-term exposure of the general population, i. e. 5.57 mg/kg bw/day. In addition, fragranced end-products meant for use by the general public contain low amounts of methyl benzoate, generally < 1%. Enzyme-driven hydrolysis of methyl benzoate in organisms releases methanol in equimolar amounts. The proposed DNEL for methyl benzoate of 5.57 mg/kg bw/day is equivalent to a methanol dose of 1.3 mg/kg bw/day. According to the ECHA dissemination page, the DNEL for effects of short-term oral exposure to methanol is 8 mg/kg bw/day. Hence, the oral dose of methanol of 1.3 mg/kg bw/day is clearly below this oral DNEL. It can be concluded that methanol is likely to have low contribution to the acute oral toxicity of methyl benzoate. A detailed assessment of methanol exposure therefore is not required.
The acute/short term exposure inhalation and dermal DNELs for local effects was not derived, since no local irritation potential could be identified in skin and eye irritation studies and therefore, no hazard was identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.