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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-259-7 | CAS number: 93-58-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 14.8 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 370 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 5
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.2 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 420 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 5
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Selection of the relevant dose descriptors:
NOAEL(repeated dose toxicity) = 300 mg/kg bw/d
NOAEL(developmental toxicity) = 500 mg/kg bw/d
Modification of the relevant dose descriptors to the correct starting point:
Oral absorption
The physicochemical properties of the substance are favourable for oral absorption (molecular weight = 136.15 g/mol, log Kow = 2.24). Therefore, the default value of 50% is taken into consideration dermal (Guidance on Information Requirements and Chemical Safety Assessment, R8).
Dermal absorption
The physicochemical properties of the substance are favourable for dermal absorption (molecular weight = 136.15 g/mol, log Kow = 2.24). Therefore, the default correction factor for route-to-route extrapolation from oral to dermal (Guidance on Information Requirements and Chemical Safety Assessment, R8).
Inhalation absorption
The physicochemical properties of the substance are favourable for inhalation absorption (molecular weight = 136.15 g/mol, log Kow = 2.24). Therefore, default correction factor for route-to-route extrapolation from oral to inhalation (Guidance on Information Requirements and Chemical Safety Assessment, R8).
Correction parameters used:
Correction for differences in respiratory volume (worker) | 2.63 |
Correction for light activity at work | 0.67 |
Correction for differences between human and experimental exposure conditions (worker) | 1.4 |
DNELs derived from the 90 d repeated dose toxicity study
Starting point: 300 mg/kg bw/d NOAEL(repeated dose toxicity)
Route of original study: oral
Worker-DNEL long-term for inhalation route (systemic): 14.8 mg/m³
Worker-DNEL long-term for dermal route (systemic): 4.2 mg/kg bw/d
Assessment factors used:
AF for dose response relationship | 1 (Default (DNEL calculator)) |
AF for difference in duration of exposure | 2 (Default (DNEL calculator)) |
AF for interspecies differences (allometric scaling) | 1 (Default (DNEL calculator)) for inhalation
4 (Default (DNEL calculator)) for dermal exposure |
AF for other interspecies differences | 2.5 (Default (DNEL calculator)) |
AF for intraspecies differences | 5 (Default (DNEL calculator)) |
AF for the quality of the whole database | 1 (Default (DNEL calculator)) |
AF for remaining uncertainties | 1 (no remaining uncertainties) |
Overall assessment factor | 25 (inhalation) 100 (oral) |
DNELs derived from the prenatal developmental toxicity study
Starting point: 500 mg/kg bw/d NOAEL (developmental toxicity)
Route of original study: oral
Worker-DNEL long-term for inhalation route (systemic): 49.3 mg/m³
Worker-DNEL long-term for dermal route (systemic): 14 mg/kg bw/d
Assessment factors
AF for dose response relationship | 1 (Default (DNEL calculator)) |
AF for difference in duration of exposure | 1 (no time extrapolation required, since the susceptible window is fully covered) |
AF for interspecies differences (allometric scaling) | 1 (Default (DNEL calculator)) for inhalation
4 (Default (DNEL calculator)) for dermal exposure |
AF for other interspecies differences | 2.5 (Default (DNEL calculator)) |
AF for intraspecies differences | 5 (Default (DNEL calculator)) |
AF for the quality of the whole database | 1 (Default (DNEL calculator)) |
AF for remaining uncertainties | 1 (no remaining uncertainties) |
Overall assessment factor | 12.5 (inhalation) 50 (oral) |
The DNELs for developmental toxicity are higher than those for repeated dose toxicity. Thus, the repeated dose toxicity-DNELs are also protective for development.
Short-term systemic effects
The acute/short term inhalation DNEL for systemic effects was not required, since the substance is unlikely to exert significant acute toxicity via the inhalation route.
The acute/short term exposure dermal DNEL for systemic effects was not derived, since no hazard was identified for Methyl benzoate for dermal toxicity. It is anticipated that incidences of potential acute dermal exposure to the substance are covered with the DNEL for dermal long-term exposure of workers.
Long-term local effects
The long-term inhalation and dermal DNELs for local effects were not derived, since no local irritation potential was identified in skin irritation studies and only slight, transient effects on conjunctivae were observed.
Short-term local effects
The acute/short term inhalation and dermal DNELs for local effects were not derived, since no local irritation potential was identified in skin irritation studies and only slight, transient effects on conjunctivae were observed.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.61 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 131 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 300 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- AF for dose response relationship:
- 1
- Justification:
- Default (DNEL calculator)
- AF for differences in duration of exposure:
- 2
- Justification:
- Default (DNEL calculator)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default (DNEL calculator)
- AF for other interspecies differences:
- 2.5
- Justification:
- Default (DNEL calculator)
- AF for intraspecies differences:
- 10
- Justification:
- Default (DNEL calculator)
- AF for the quality of the whole database:
- 1
- Justification:
- Default (DNEL calculator)
- AF for remaining uncertainties:
- 1
- Justification:
- no remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Selection of the relevant dose descriptors:
NOAEL(repeated dose toxicity) = 300 mg/kg bw/d
NOAEL(developmental toxicity) = 500 mg/kg bw/d
Modification of the relevant dose descriptors to the correct starting point:
Oral absorption
The physicochemical properties of the substance are favourable for oral absorption (molecular weight = 136.15 g/mol, log Kow = 2.24). Therefore, the default value of 50% is taken into consideration dermal (Guidance on Information Requirements and Chemical Safety Assessment, R8).
Dermal absorption
The physicochemical properties of the substance are favourable for dermal absorption (molecular weight = 136.15 g/mol, log Kow = 2.24). Therefore, the default correction factor for route-to-route extrapolation from oral to dermal (Guidance on Information Requirements and Chemical Safety Assessment, R8).
Inhalation absorption
The physicochemical properties of the substance are favourable for inhalation absorption (molecular weight = 136.15 g/mol, log Kow = 2.24). Therefore, default correction factor for route-to-route extrapolation from oral to inhalation (Guidance on Information Requirements and Chemical Safety Assessment, R8).
Correction parameters used:
Correction for differences in respiratory volume (general population) | 0.87 |
Correction for differences between human and experimental exposure conditions (general population) | 1 |
DNELs derived from the 90 d repeated dose toxicity study
Starting point: 300 mg/kg bw/d NOAEL(repeated dose toxicity)
Route of original study: oral
General population-DNEL long-term for inhalation route (systemic): 2.61 mg/m³
General population-DNEL long-term for dermal route (systemic): 1.5 mg/kg bw/d
General population-DNEL long-term for dermal route (systemic): 1.5 mg/kg bw/d
Assessment factors used:
AF for dose response relationship | 1 (Default (DNEL calculator)) |
AF for difference in duration of exposure | 2 (Default (DNEL calculator)) |
AF for interspecies differences (allometric scaling) | 1 (Default (DNEL calculator)) for inhalation
4 (Default (DNEL calculator)) for dermal and oral exposure |
AF for other interspecies differences | 2.5 (Default (DNEL calculator)) |
AF for intraspecies differences | 10 (Default (DNEL calculator)) |
AF for the quality of the whole database | 1 (Default (DNEL calculator)) |
AF for remaining uncertainties | 1 (no remaining uncertainties) |
Overall assessment factor | 50 (inhalation) 200 (dermal and oral) |
DNELs derived from the prenatal developmental toxicity study
Starting point: 500 mg/kg bw/d NOAEL (developmental toxicity)
Route of original study: oral
General population-DNEL long-term for inhalation route (systemic): 8.7 mg/m³
General population-DNEL long-term for dermal route (systemic): 5 mg/kg bw/d
General population-DNEL long-term for oral route (systemic): 5 mg/kg bw/d
Assessment factors
AF for dose response relationship | 1 (Default (DNEL calculator)) |
AF for difference in duration of exposure | 1 (no time extrapolation required, since the susceptible window is fully covered) |
AF for interspecies differences (allometric scaling) | 1 (Default (DNEL calculator)) for inhalation
4 (Default (DNEL calculator)) for dermal exposure |
AF for other interspecies differences | 2.5 (Default (DNEL calculator)) |
AF for intraspecies differences | 10 (Default (DNEL calculator)) |
AF for the quality of the whole database | 1 (Default (DNEL calculator)) |
AF for remaining uncertainties | 1 (no remaining uncertainties) |
Overall assessment factor | 25 (inhalation) 100 (dermal and oral) |
The DNELs for developmental toxicity are higher than those for repeated dose toxicity. Thus, the repeated dose toxicity-DNELs are also protective for development.
Short-term systemic effects
The acute/short term inhalation DNEL for systemic effects was not required, since the substance is unlikely to exert significant acute toxicity via the inhalation route.
The acute/short term exposure dermal DNEL for systemic effects was not derived, since no hazard was identified for Methyl benzoate for dermal toxicity. It is anticipated that incidences of potential acute dermal exposure to the substance are covered with the DNEL for dermal long-term exposure of workers.
Long-term local effects
The long-term inhalation and dermal DNELs for local effects were not derived, since no local irritation potential was identified in skin irritation studies and only slight, transient effects on conjunctivae were observed.
Short-term local effects
The acute/short term inhalation and dermal DNELs for local effects were not derived, since no local irritation potential was identified in skin irritation studies and only slight, transient effects on conjunctivae were observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.