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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl benzoate
EC Number:
202-259-7
EC Name:
Methyl benzoate
Cas Number:
93-58-3
Molecular formula:
C8H8O2
IUPAC Name:
methyl benzoate

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
Not reported

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Animals were given a single application of 2000 mg/kg. Collars were placed on each animal.
Duration of exposure:
Single application, 14 days of observation
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occurred
Clinical signs:
other: No treatment-related clinical signs were observed
Gross pathology:
No findings
Other findings:
Irritation of the skin was seen at the application site.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 value after a single application of methyl benzoate to the skin of male and female rabbits was > 2000 mg/kg. No mortality occurred during the observation period of 14 days.
Executive summary:

The dermal acute toxicity of methyl benzoate was tested under GLP according to OECD TG 402. A single dose of 2000 mg/kg was applied to the skin of healthy male and female rabbits of the strain New Zealand White. Five animals per sex were tested and observed during a period of 14 days after treatment. A collar was placed on the treated animals. No mortality occurred after dermal treatment or during the observation period. Irritation of the skin was noted at the application site. Four male and three female rabbits had reduced body weights on day 1 and one female had reduced body weight during days 4 to 7. No gross findings were reported at necropsy. The LD50 value after a single application of methyl benzoate to the skin of rabbits was greater than 2000 mg/kg bw.