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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient documented for evaluation

Data source

Reference
Reference Type:
publication
Title:
Studies on allergenic sensitization to certain topical therapeutic agents
Author:
Baer R, Serri F, Weissenbach-Vial C
Year:
1955
Bibliographic source:
Arch Dermatol 71, 19-23

Materials and methods

Type of sensitisation studied:
skin
Study type:
other: patients were tested
Principles of method if other than guideline:
Allergic hypersensitivity was investigated in a group of 228 selected dermatologic patients by patch tests with menthol 1 % in petrolatum
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Type of population:
general
Controls:
no data
Route of administration:
dermal

Results and discussion

Results of examinations:
Allergic hypersensitivity was investigated in a group of 228 selected dermatologic patients by patch tests with menthol 1 % in petrolatum; incidence of pronounced sensitization: 1.3 %.

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

Allergic hypersensitivity was investigated in a group of 228 selected dermatologic patients by patch tests with menthol 1 % in petrolatum; incidence of pronounced sensitization: 1.3 %.