Registration Dossier
Registration Dossier
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EC number: 201-939-0 | CAS number: 89-78-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient documented for evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on allergenic sensitization to certain topical therapeutic agents
- Author:
- Baer R, Serri F, Weissenbach-Vial C
- Year:
- 1 955
- Bibliographic source:
- Arch Dermatol 71, 19-23
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: patients were tested
- Principles of method if other than guideline:
- Allergic hypersensitivity was investigated in a group of 228 selected dermatologic patients by patch tests with menthol 1 % in petrolatum
- GLP compliance:
- no
Test material
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
Constituent 1
Method
- Type of population:
- general
- Controls:
- no data
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- Allergic hypersensitivity was investigated in a group of 228 selected dermatologic patients by patch tests with menthol 1 % in petrolatum; incidence of pronounced sensitization: 1.3 %.
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Executive summary:
Allergic hypersensitivity was investigated in a group of 228 selected dermatologic patients by patch tests with menthol 1 % in petrolatum; incidence of pronounced sensitization: 1.3 %.
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