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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Reference
Reference Type:
publication
Title:
Report to RIFM, February 16, 1973
Author:
Opdyke DLJ
Year:
1976
Bibliographic source:
Kligman, A.M.: Report to RIFM, February 12, 1973: : cited in Opdyke, D.L.J.: Fd Cosmet. Toxicol. 14, 473-474 (1976)

Materials and methods

Study type:
not specified
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
patch-test with menthol
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Subjects:
human subjects
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
measured

Results and discussion

Clinical signs:
irritation

Any other information on results incl. tables

menthol racemic (8% in petrolatum) produced no irritation after a 48 h closed-patch test in human subjects

Applicant's summary and conclusion

Executive summary:

menthol racemic (8% in petrolatum) produced no irritation after a 48 h closed-patch test in human subjects