Registration Dossier
Registration Dossier
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EC number: 201-939-0 | CAS number: 89-78-1
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Report to RIFM, February 16, 1973
- Author:
- Opdyke DLJ
- Year:
- 1 976
- Bibliographic source:
- Kligman, A.M.: Report to RIFM, February 12, 1973: : cited in Opdyke, D.L.J.: Fd Cosmet. Toxicol. 14, 473-474 (1976)
Materials and methods
- Study type:
- not specified
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- patch-test with menthol
- GLP compliance:
- no
Test material
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
Constituent 1
Method
- Subjects:
- human subjects
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
Results and discussion
- Clinical signs:
- irritation
Any other information on results incl. tables
menthol racemic (8% in petrolatum) produced no irritation after a 48 h closed-patch test in human subjects
Applicant's summary and conclusion
- Executive summary:
menthol racemic (8% in petrolatum) produced no irritation after a 48 h closed-patch test in human subjects
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