Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature

Data source

Reference
Reference Type:
publication
Title:
Report to RIFM, February 16, 1973
Author:
Opdyke DLJ
Year:
1976
Bibliographic source:
Kligman, A.M.: Report to RIFM, February 12, 1973: : cited in Opdyke, D.L.J.: Fd Cosmet. Toxicol. 14, 473-474 (1976)

Materials and methods

Study type:
not specified
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
patch-test with menthol
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Menthol
EC Number:
201-939-0
EC Name:
Menthol
Cas Number:
89-78-1
Molecular formula:
C10H20O
IUPAC Name:
2-isopropyl-5-methylcyclohexanol

Method

Subjects:
human subjects
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
measured

Results and discussion

Clinical signs:
irritation

Any other information on results incl. tables

menthol racemic (8% in petrolatum) produced no irritation after a 48 h closed-patch test in human subjects

Applicant's summary and conclusion

Executive summary:

menthol racemic (8% in petrolatum) produced no irritation after a 48 h closed-patch test in human subjects