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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Principles of method if other than guideline:
HPLC method
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: purchased from Aldrich (Castle Hill, Australia) and Fluka (Castle Hill, Australia).

OTHER SPECIFICS:
The standard compounds and terpenoirds were of 95 % purity or greater as determined by gas chromatography (GC)

Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.4
Temp.:
37 °C
pH:
7.2
Details on results:
Log Pow of 3.4 for L- and DL-Menthol

For the test substance, the capacity factor was calculated and the logKow value was determined with reference to the calibration curve.

Conclusions:
The partition coefficient of DL-Menthol is 3.4 at 37°C and pH 7.2.
Executive summary:

The partition coefficient (log Pow) of 3.4 at 37°C and pH 7.2 is determined for DL-Menthol using the HPLC method.

Description of key information

The partition coefficient (log Pow) of 3.4 at 37°C and pH 7.2 is determined for DL-Menthol using the HPLC method.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.4
at the temperature of:
37 °C

Additional information

Other literatures report values of 3.23 at 43 °C (Suzuki 1991) and 3.79 and 3.3 (Beilstein 2009) for Menthol, which vary in the same range.