Menthol

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

HPLC method

GLP compliance:

not specified

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: purchased from Aldrich (Castle Hill, Australia) and Fluka (Castle Hill, Australia).

OTHER SPECIFICS:
The standard compounds and terpenoirds were of 95 % purity or greater as determined by gas chromatography (GC)

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

3.4

Temp.:

37 °C

pH:

7.2

Details on results:

Log Pow of 3.4 for L- and DL-Menthol

For the test substance, the capacity factor was calculated and the logKow value was determined with reference to the calibration curve.

Conclusions:

The partition coefficient of DL-Menthol is 3.4 at 37°C and pH 7.2.

Executive summary:

The partition coefficient (log Pow) of 3.4 at 37°C and pH 7.2 is determined for DL-Menthol using the HPLC method.

Description of key information

The partition coefficient (log Pow) of 3.4 at 37°C and pH 7.2 is determined for DL-Menthol using the HPLC method.

Key value for chemical safety assessment

Log Kow (Log Pow):

3.4

at the temperature of:

37 °C

Additional information

Other literatures report values of 3.23 at 43 °C (Suzuki 1991) and 3.79 and 3.3 (Beilstein 2009) for Menthol, which vary in the same range.