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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient documented for evaluation

Data source

Reference
Reference Type:
publication
Title:
Food flavourings and compounds of related structure I. Acute oral toxicity
Author:
Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG
Year:
1964
Bibliographic source:
Fd. Cosmet. Toxicol. 2, 327-343

Materials and methods

Principles of method if other than guideline:
Groups of 10 young adult Osborne-Medel rats were given menthol by intubation. Animals were observed for 2 weeks during which time the development of toxic signs were followed and time of death noted. The acute oral LD50 was determined.
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
OTHER SPECIFICS: Menthol (p-menthan-3-ol)

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
no data
No. of animals per sex per dose:
5 males + 5 females/group
Control animals:
not specified

Results and discussion

Effect levels
Key result
Dose descriptor:
LD50
Effect level:
3 180 mg/kg bw

Any other information on results incl. tables

toxic signs: ataxia, scrwny appearance

death time: 4 hr - 3 days

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 was 3180 mg/kg bw (rat, male/female)
Executive summary:

Groups of 10 young adult Osborne-Medel rats were given menthol by intubation. Animals were observed for 2 weeks during which time the development of toxic signs were followed and time of death noted.

The acute oral LD50 was 3180 mg/kg bw (rat, male/female)