Registration Dossier

Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special study

Data source

Reference
Reference Type:
publication
Title:
Glucuronidation of 7-hydroxy-4-methyl-coumarin by liver microsomes. Inhibition by certain drugs
Author:
Irshaid YM, Gharaybeh KI, Ammari FF, Rawshdeh NM
Year:
1990
Bibliographic source:
Eur J Drug Metabolism and Pharmacokinetics 15, 295-301

Materials and methods

Principles of method if other than guideline:
In an in vitro study with human liver samples the glucuronidation of 7-hydroxy-4-methylcoumarin (7-0H-4-MC) in the presence of menthol (isomer unspec.) was measured
GLP compliance:
not specified
Type of method:
in vitro
Endpoint addressed:
basic toxicokinetics

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Menthol was purchased from Sigma Chmical Co. (no data on purity)

Test animals

Species:
human
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: in-vitro experiment
Vehicle:
other: in-vitro experiment
Duration of treatment / exposure:
not applicable (in-vitro experiment)
Frequency of treatment:
not applicable (in-vitro experiment)
Post exposure period:
not applicable (in-vitro experiment)
Doses / concentrations
Remarks:
Doses / Concentrations:
not applicable (in-vitro experiment)
Basis:

No. of animals per sex per dose:
not applicable (in-vitro experiment)

Results and discussion

Details on results:
In an in vitro study with human liver samples menthol (isomer unspec.) inhibited the glucuronidation of 7-hydroxy-4-methylcoumarin (45 % inhibition).

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

In an in vitro study with human liver samples menthol (isomer unspec.) inhibited the glucuronidation of 7 -hydroxy-4 -methylcoumarin ( 45% inhibition).