Registration Dossier
Registration Dossier
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EC number: 201-939-0 | CAS number: 89-78-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: few experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Investigation on value of the maximum allowable concnetration of natural essential oils in the air
- Author:
- Kowalski Z, Dutkiewicz T, Szmczykiewicz K
- Year:
- 1 962
- Bibliographic source:
- Medycyna Pracy 13, 69-83 (abstr.)
Materials and methods
- Principles of method if other than guideline:
- In order to determine the value of the maximum allowable concentration (MAC) of vapours of 9 essential oils and menthol the experimental in- _
vestigations on acute and chronic intoxications resulted from these substances (on, 530 white mice). - GLP compliance:
- no
Test material
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 months
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.05 or 0.1 mg/l
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 10 mg/L air (nominal)
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
After three month exposure to menthol in concentrations of 0,1 and 0,05 mg/l there were observed regressive changes in the liver and Kidney of the white mice representing the symptoms of the chronic intoxication.
Applicant's summary and conclusion
- Executive summary:
In order to determine the value of the maximum allowable concentration (MAC) of vapours of 9 essential oils and menthol the experimental investigations on acute and chronic intoxications resulted from these substances (on, 530 white mice).
After three month exposure to menthol in concentrations of 0,1 and 0,05 mg/l there were observed regressive changes in the liver and Kidney of the white mice representing the symptoms of the chronic intoxication.
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