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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: few experimental details

Data source

Reference
Reference Type:
publication
Title:
Investigation on value of the maximum allowable concnetration of natural essential oils in the air
Author:
Kowalski Z, Dutkiewicz T, Szmczykiewicz K
Year:
1962
Bibliographic source:
Medycyna Pracy 13, 69-83 (abstr.)

Materials and methods

Principles of method if other than guideline:
In order to determine the value of the maximum allowable concentration (MAC) of vapours of 9 essential oils and menthol the experimental in- _
vestigations on acute and chronic intoxications resulted from these substances (on, 530 white mice).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
3 months
Frequency of treatment:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
0.05 or 0.1 mg/l
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Post-exposure period: no data

Results and discussion

Effect levels

Dose descriptor:
NOAEC
Effect level:
10 mg/L air (nominal)
Based on:
test mat.
Sex:
not specified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

After three month exposure to menthol in concentrations of 0,1 and 0,05 mg/l there were observed regressive changes in the liver and Kidney of the white mice representing the symptoms of the chronic intoxication.

Applicant's summary and conclusion

Executive summary:

In order to determine the value of the maximum allowable concentration (MAC) of vapours of 9 essential oils and menthol the experimental investigations on acute and chronic intoxications resulted from these substances (on, 530 white mice).

After three month exposure to menthol in concentrations of 0,1 and 0,05 mg/l there were observed regressive changes in the liver and Kidney of the white mice representing the symptoms of the chronic intoxication.