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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documented

Data source

Reference
Reference Type:
publication
Title:
Synthetisches Menthol
Author:
Flury F, Seel H
Year:
1926
Bibliographic source:
Muenchener Medizinische Wochenschrift 48, 2011-2012

Materials and methods

Principles of method if other than guideline:
subcutaneous application of menthol in rats.Clinical signs and lethality was determined.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Menthol
EC Number:
201-939-0
EC Name:
Menthol
Cas Number:
89-78-1
Molecular formula:
C10H20O
IUPAC Name:
2-isopropyl-5-methylcyclohexanol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw

Any other information on results incl. tables

rats are more sensitive than mice

Applicant's summary and conclusion

Executive summary:

LD50 of menthols from natural sources and synthetically produced was 1000 to 2500 mg/kg bw in rats