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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: insufficient documented

Data source

Reference
Reference Type:
publication
Title:
Synthetisches Menthol
Author:
Flury F, Seel H
Year:
1926
Bibliographic source:
Muenchener Medizinische Wochenschrift 48, 2011-2012

Materials and methods

Principles of method if other than guideline:
subcutaneous application of menthol in rats.Clinical signs and lethality was determined.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw

Any other information on results incl. tables

rats are more sensitive than mice

Applicant's summary and conclusion

Executive summary:

LD50 of menthols from natural sources and synthetically produced was 1000 to 2500 mg/kg bw in rats