Registration Dossier
Registration Dossier
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EC number: 201-939-0 | CAS number: 89-78-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: insufficient documented
Data source
Reference
- Reference Type:
- publication
- Title:
- Synthetisches Menthol
- Author:
- Flury F, Seel H
- Year:
- 1 926
- Bibliographic source:
- Muenchener Medizinische Wochenschrift 48, 2011-2012
Materials and methods
- Principles of method if other than guideline:
- subcutaneous application of menthol in rats.Clinical signs and lethality was determined.
- GLP compliance:
- no
Test material
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
Any other information on results incl. tables
rats are more sensitive than mice
Applicant's summary and conclusion
- Executive summary:
LD50 of menthols from natural sources and synthetically produced was 1000 to 2500 mg/kg bw in rats
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