Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-939-0 | CAS number: 89-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Hydrolysis
Data waiving:
In accordance with REACH Annex VIII column 2, the study does not need to be conducted if the substance is readily biodegradable.
Biodegradation
Ready biodegradability:
Read-across:
A closed bottle test comparable to OECD TG 301 D under aerobic conditions was performed and after 21 days a maximum percentage of 93 % biodegradation of L-Menthol (CAS no. 2216 -51 -5) was reached in a test with an initial concentration of 0.84 mg/L. 79 % of D-Menthol was degraded in a test with an initial concentration of 2.00 mg/L aftre 28 days. Therefore, L-Menthol is considered being readily biodegradable.
A closed bottle test comparable to OECD TG 301 D under aerobic conditions was performed and after 28 days 92 % of D-Menthol (CAS no. 15356-60-2) was degraded in a test with an initial concentration of 0.84 mg/L. 76 % of D-Menthol was degraded in a test with an initial concentration of 2.01 mg/L. Therefore, D-Menthol is considered being readily biodegradable.
Inherent biodegradability:
A test on inherent biodegradation comparable to OECD TG 302 B was performed with a duration of 5 days. 95.1 % of DL-Menthol was degraded during the test period. Therefore, DL-Menthol is considered being inherent biodegradable.
Bioaccumulation:
In a bioaccumulation test, corresponding to OECD Guideline 305C, a BCF of <0.5 - 15 at 0.2 mg/L and <4.6 - 11 at 0.02 mg/L test concentration for DL-Menthol was determined with Cyprinus carpio as test organism (15 - 20 animals/concentration) within 6 weeks.
Adsorption / desorption:
The QSAR determination of the carbon partition coefficient for DL-Menthol using the model KOCWIN included in the Estimation Program Interface (EPI) Suite v4.1 revealed values of 247.9 L/kg (logKow method) and 88.15 L/kg (MCI method) for the unaffected molecule of the substance as any decomposition (e.g. hydrolysis) of the substance is not taken into account by the program.
Additional information
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