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EC number: 239-622-4
CAS number: 15571-58-1
Skin irritation : two guideline study (OECD 404) were available in rabbits.Eye irritation : a guideline study (OECD 405) was available in rabbits.
Acute Dermal Irritation / Corrosion GLP test performed according to OECD
404 was carried out with DOT(2
-EHMA) (purity>98%). The test substance was applied undiluted on a patch
on shaved rabbit skin. The test material induced slight to moderate
erythema on all rabbits and very slight edema on four animals. Three
rabbits had desquamation. There were no other dermal findings. All
irritations were reversible and completely subsided at day 11 or earlier.
Primary Irritation Index was calculated to be 2.2.Under
the experimental conditions, the test substance was classified as a
Eye irritation :
One in vivo rabbit eye
irritation GLP study performed according to OECD 405 was carried out
with DOT(2 -EHMA) (purity>98%). The test substance was instilled
undiluted in the right lower conjunctival sac. Minor conjunctival
irritation was observed, and no iris or corneal effects. Effects were
fully reversible within 96h. The test substance was not considered as an
Skin irritation :
According to Directive 67/548/EEC, DOT(2
-EHMA) is classified as R38 'Irritating to skin'.
Justification : There are 5/6 rabbits with a
erythema score of 2 or more (mean values of 24, 48 and 72 hours). None
of 6/6 rabbits have edema score of 2 or more. All effects were fully
According to Regulation EC no.1272/2008
(CLP), DOT(2 -EHMA) is not classified as skin irritant.
Justification : There are only 1 rabbit with
a erythema score of 2.3 or more (mean values of 24,48 and 72 hours).
None of 6 rabbits have a edema score of 2.3 or more. All effects were
Based on the results of the key study for
eye irritation, DOT(2 -EHMA) is not classified for eye irritation
according to Regulation EC no.1272/2008 (CLP) and according to Directive
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