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EC number: 239-622-4
CAS number: 15571-58-1
Under the conditions studied, ZK
30 434 failed to show any evidence of mutagenic potential when
administered orally in this test procedure. However, evidence of bone
marrow depression was observed.
*** p< 0.001
The effect of ZK 30 434 on the incidence of micronucleated polychromatic
erythrocytes from the bone marrow of mice was tested with doses of 2250,
4500, and 9000 mg/kg bodyweight administered by oral gavage in two equal
doses separated by an interval of 24 hours. Negative control (1%
methycellulose by oral gavage) and postive control group (14 mg/kg
mitomycin C by injection) were run concurrently. After 6 hours of the
second dose bone marrow smears were examined for the presence of
micronuclei in 2000 polychromatic and 2000 normochromatic erythorcytes
At all doses of ZK 30 434 both the group mean micronucleated cell counts
were comparable with the concurrent control values. The ratio of
normochromatic to polychromatic cells was comparable to controls for
2250 mg/kg group and significantly higher for 4500 and 9000 mg/kg groups
(by Kruskal-Wallis method). Postive control produced expected increase
in micronucleated cell count and ratio. It was concluded that ZK 30 434
failed to show any evidence of mutagenic potential when adminsitered
orally in the test procedure. However, evidence of bone marrow
depression was observed, which is an indication that the test item
reached the bone marrow.
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