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EC number: 239-622-4
CAS number: 15571-58-1
A dermal absorption study was carried out
with DOT(2 -EHMA). Absorption of tins compounds
was determined via both occluded and unoccluded applications to human and rat epidermis.
Of the recovered tin, 2.1% (human) and 5.5% (rat) were obtained from the surface of the epidermis and donor chamber. The mean amounts of tin
absorbed by 24 hours were 0.010 ug/cm2 (unoccluded) and 0.011 ug/cm2 (occluded) through human epidermis and 0.641 ug/cm2 (unoccluded)
and 0.547ug/cm2 (occluded) through rat epidermis.
The results show that the absorption of tin from dioctyltin bis(2-ethylhexylmercaptoacetate) through rat epidermis significantly
overestimated absorption from human epidermis. By 24 hours only a small
amount of the applied tin (3% in human and 1% in the rat)
is associated with the epidermis and is not regarded as systemically available.
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