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EC number: 239-622-4
CAS number: 15571-58-1
The aquatic toxicity profile of DOTE has been well characterized through
several short-term tests and one long-term Daphnia reproduction test.
The analysis of the existing data tends to demonstrate that test
implementation is complex based on DOTE’s intrinsic properties such
as low water solubility and in water. The protocols were designed to
address those technical issues.
In the key study conducted in fish, a Water Accommodated Fraction (WAF)
was prepared at a loading rate of 100 mg/L and subsequent dilutions
containing 0.1, 1.0 and 10 % of the WAF were also prepared. DOTE induced
no visible effects in zebra-fish (Brachydanio rerio) at or below a WAF
prepared at the loading rate of 100 mg/L over 96 hours. Based on average
measured concentrations the NOEC corresponded to 24.8 mg DOTE per litre
(3.91 mg tin per litre).
The analytical methodology followed was the analysis of total tin, from
which the DOTE concentration was calculated. In this context, the 96 h
LC50 > 24.8 mg/L, therefore no effects were observed up to the water
solubility limit of DOTE.
In the key study conducted in daphnia, it
can be concluded that the 48 hour acute median effective concentration
(EC50) of DOTE on Daphnia is 24.12 mg/L
In the key long-term Daphnia reproduction test (21 days) daphnids were
exposed to the test material at concentrations of 33, 134, 286, 1448 and
3213 µg/L. Effects were noted at the two highest test concentrations;
however it was determined that the effects cannot necessarily be
attributed to the parent compound. It was therefore concluded that up to
the water solubility of DOTE there is no toxicity. The NOEC was
determined to be 0.286 mg/L.
The study was conducted with a test item containing ca. 3 -4 % of
Ethylhexylthioglycolate (EHTG, CAS: 7659 -86 -1, EC: 231 -626 -4) as
impurity EHTG is better soluable in water as DOTE and shows the
following ecotoxicity: EC50 (48 h) Daphnia = 0.38 mg/L EC50 Algae = 0.41
mg/L and is thus classified as Aquatic Acute 1 H400 and Aquatic Chroinic
H410 Is likely that the observed effects in the study are caused or
exacerbated by the impurity EHTG
In the Key
under the experimental conditions employed, it can be concluded that the
growth rate ErC50and inhibition in the yield EyC50for
the test item DOTE was greater than 100.0 mg/L.The
No Observed Adverse Effect Concentration (NOAEC) over the 72 hours
exposure period was also greater than 100.0 mg/L of DOTE.
The 3 hour EC50 for DOTE for inhibiting the respiration of aerobic
wastewater bacteria has been determined to be > 100 mg/L.
In several of the studies, exposure concentrations were not stable over
the test period. Loss of the test material may be due to adsorption onto
test vessels or incorporation of the test material in the algae biomass.
The test material is poorly soluble in water but contains reactive
ligands that can be readily hydrolysed in water, resulting in
more-soluble compounds (e.g., hydroxides and oxides). Organotin
impurities, including these hydrolysis reaction products, will be
present in solution along with the named substance. At least some of
these impurities are more soluble in water than the named substance.
Poor solubility and the occurrence of hydrolysis reactions present
significant challenges to testing organotin compounds in aqueous
solutions. It is highly probable that any toxicity seen is not entirely
due to the named substance only.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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