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EC number: 239-622-4
CAS number: 15571-58-1
-Acute oral: several studies are available. The study of 1992 was choosen as key study because DOTE with a purity of 90% was used in this study (the others studies "klimisch 2" used DOTE with a purity smaller than 90% or DOTC).-Acute dermal : two key studies were available.-No information on acute inhalation toxicity was available.
robust acute oral toxicity rat study (OECD guideline 401) was carried
out with a mixture of DOT (2 -EHMA) and MOT(2 -EHMA) (90:10%). Two doses of
1000 and 2000 mg/kg bw were tested (single dose) with a 14 -days
observation period. Animals in both dose groups exhibited clinical signs
of toxicity and effects on mortality were observed. The LD50 was lower
than 2000 mg/kg for female rats, the overall LD50 for males and females
was 2000 mg/kg bw (lower 95% confidence limit= 1265 mg/kg/bw) ('Acute
toxicity category 4' / H302, harmful if swallowed according to GHS).
Acute dermal :
robust acute dermal toxicity rat study (OECD guideline 402) was carried
out with a mixture of DOT(2 -EHMA) and Octyltin tris(2-EHMA) (90:10 %
dose was 2000 mg/kg bw; the dose volume applied was 2 ml/kg bw. After
24 hours, the exposed skin was cleaned and the area of application was
observed for 14 days. Due to the lack of observed mortality, the 14-day
acute dermal LD50s of the test substance were reported as: LD50 (both
sexes) >2000 mg/kg bw.
other study was carried out with a mixture of DOT (2 -EHMA) and MOT(2
-EHMA) (70:30%), the same result is observed : LD50 > 2000 mg/kg bw.
Acute inhalation :
Acute oral :
Based on the observed oral LD50 value, DOT(2
-EHMA) is classified with R22 according to Directive 67/548/EEC and
'Acute toxicity category 4' (H302, harmful if swallowed) according to
Regulation EC No.1272/2008 (CLP). Justification : LD50 = 2000 mg/kg bw.
Based on the acute dermal toxicity study,
classification is not warranted according to Directive 67/548/EEC and
Regulation EC No.1272/2008 (CLP).
: LD50> 2000 mg/kg bw.
Acute Inhalation :
not classified be because no study
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