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EC number: 239-622-4
CAS number: 15571-58-1
Table 1. Individual ocular
irritation scores for conjuctiva.
Table 2. Individual body
The preliminary ocular irritation potential of diocotylitin bis
(2-ethylhexylmecaptoacetate) was evaluated in this study using New
Zealand White Rabbits. Single 0.1 mL doses of the test material were
instilled inot the lower conjuctival sac of the right eye of 6 albino
rabbits. The eyelids were held closed for approximately 1 second and
released. Left eyes were manipulated in a similar manner as the right
eyes and served as contralateral controls. The eyes of all animals
The eyes were examined for ocular reactions in accordance with the
method of Draize at approximately 1, 24, 48, and 72 hours after dosing
and on day 4 if irritation persisted. Sodium fluorescein was used to aid
in revealing possible corneal damage at 24, 48, and 72 hours and on day
4. Postive conjunctival reactions were noted in the treated eye of 4
animals while minor conjuctival irritation was noted for all rabbits.
There were no corneal or iridal findings. All irritation was reversible
and completely subsided by day 4 or earlier.
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