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EC number: 239-622-4
CAS number: 15571-58-1
In a long-term Daphnia reproduction test (21 days) it can be concluded that up to the water solubility of DOT(EHMA) there is no toxicity. The NOEC was determined to be 0.286 mg/L.
In a semi-static design, ten daphnids per concentration were
individually exposed to dilutions containing 1, 5, 10, 50 and 100% of
the WAF prepared at 100 mg/L, and twenty daphnids were individually
exposed to untreated test medium (blank control). Test solutions were
renewed three times a week. The total test period was 21 days. Samples
for analysis were taken from all test solutions at the start and the end
of the first, third, sixth and eighth renewal interval. Additionally,
samples were taken from the freshly prepared highest test solution at
the start of the fifth, seventh and ninth interval.
Analytical results were consistent within the groups and remained stable
during the periods between media changes. Reported exposure
concentrations for each group were calculated by taking the mean of
analytical results of whole intervals for the group. Thus, average
exposure concentrations were as follows:
As WAF: 1, 5, 10, 50 and 100%
As Sn: 5.2, 21, 46, 229 and 508 µg/L
As DOT(EHMA): 33, 134, 286, 1448 and 3213 µg/L
Sn was not detected in control samples, except for one occasion, when a
4.1 µg/L concentration was measured.
None of the twenty parental daphnids died during the test period in the
control. Incidental mortalities occurred at all but the lowest treatment
level, with 1, 1, 2 and 2 dead parents at 134, 286, 1448 and 3213 µg/L,
respectively. Hence, parental mortality was not related to concentration.
The average cumulative number of young per reproducing female in the
control after 21 days was 134.6 ± 14.2. The reproduction curves recorded
at all the treatment levels closely followed the curve of control.
However, at the two highest test concentrations, 1448 and 3213 µg/L,
offspring included considerable numbers of immobile young. The number of
mobile offspring at the two highest treatment levels was statistically
significantly reduced. Based on total offspring produced, only the
highest treatment level showed a statistically significant reduction.
Mean body length was significantly reduced at 1448 and 3213 µg/L.
No unhatched eggs were observed in any of the concentrations tested. No
small or pale parental daphnids were observed in the control or the test
concentrations throughout the test period.
Considering the extremely low solubility of the test substance,
super-saturated solutions were prepared. In this context tested
concentrations expressed as WAF are far above the water solubility of
the test substance. Therefore the effects noticed cannot necessarily be
attributed to the parent compound.
In the frame of this long-term Daphnia reproduction test, it can just be
concluded that up to the water solubility of DOT(EHMA) there is no
Furthermore The study was conducted with a test item containing ca. 3 -4
% of Ethylhexylthioglycolate (EHTG, CAS: 7659 -86 -1, EC: 231 -626 -4)
as impurity EHTG is better soluable in water as DOTE and shows the
following ecotoxicity: EC50 (48 h) Daphnia = 0.38 mg/L EC50 Algae = 0.41
mg/L and is thus classified as Aquatic Acute 1 H400 and Aquatic Chroinic
H410 Is likely that the observed effects in the study are caused or
exacerbated by the impurity EHTG
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