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EC number: 206-108-6
CAS number: 301-10-0
Tin bis(2 -ethylhexanoate) was evaluated in the Guinea Pig Maximization
test protocol. This study was assigned a reliability rating of K-1.
Female Himalayan albino guinea pigs (SPF-quality, approximately 9 weeks
old) were used in the study. Intradermal induction concentrations were
2% w/w tin bis(2 -ethylhexanoate) in propylene glycol and also 4% tin
bis(2 -ethylhexanoate) in solution emulsified in 50:50 Freunds Complete
Adjuvant. After one week, test animals were treated with 0.5 ml of a 50%
solution of the test substance in propylene glycol applied epidermally
on a moistened patch secured with tape between the injection sites.
Control animals were treated with propylene glycol only. After 48 hours,
the dressings and residual test material were removed, and the reaction
sites were immediately assessed for erythema and edema. Test and control
guinea pigs were challenged two weeks after the epidermal application
with 10%, 5%, or 2% solutions of tin bis (2 -ethylhexanoate) in
propylene glycol. Challenge applications were performed using Square
chambers attached to Micropore tape and held in place with elastic
bandages. Dressings and residual test substance were removed after 24
hours. Sites were assessed for redness and swelling 24 and 48 hours
after removal of the dressing. In the challenge test, 20, 16 and 13 test
animals showed a positive skin reaction in response to the 10%, 5% and
2% test substance concentrations, respectively. A sensitization rate of
85% was determined. [Air Products test]
Migrated from Short description of key information:
Guinea pig sensitisation: sensitising
This study indicates that tin bis(2 -ethylhexanoate) has dermal
sensitization properties in studies in guinea pigs. Under GHS
classification, tin bis(2 -ethylhexanoate) will be labeled (Warning; May
cause allergic skin reaction).
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