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EC number: 206-108-6
CAS number: 301-10-0
An acute dermal toxicity test was conducted
with Fischer 344 rats to determine the potential for tin bis(2
-ethylhexanoate) to produce toxicity from a single topical application.
Under the conditions of this study, the single dose acute dermal LD50 of
the test substance was greater than 2,000 mg/kg of body weight in male
and female rats. 2,000 mg/kg bw was applied to the skin of ten healthy
rats for 24 hours. The test substance was initially applied to the skin
of the 5 female rats. Due to the absence of mortality of these animals,
the test substance was applied to the skin of the 5 remaining male rats.
The animals were observed for mortality, signs of gross toxicity, and
behavioral changes at least once daily for 14 days. Body weights were
recorded prior to application and again on Days 7 and 14 (termination).
Necropsies were performed on all animals at terminal sacrifice. All
animals survived exposure to the test substance, gained body weight, and
appeared active and healthy during the study. Apart from dermal
irritation (etythema) noted at the dose site of three female rats
between Days 1 and 2, and for two male rats on Day 1, there were no
other clinical findings recorded for any animal over the course of the
study. No gross abnormalities were noted for any of the animals when
necropsied at the conclusion of the 14-day observation period.
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