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EC number: 206-108-6
CAS number: 301-10-0
An acute dermal toxicity test was conducted with Fischer 344 rats to
determine the potential for tin bis(2 -ethylhexanoate) to produce
toxicity from a single topical application. Under the conditions of this
study, the single dose acute dermal LD50 of the test substance was
greater than 2,000 mg/kg of body weight in male and female rats. Two
thousand milligrams of the test substance per kilogram of body weight
was applied to the skin of ten healthy rats for 24 hours. The test
substance was initially applied to the skin of the 5 female rats. Due to
the absence of mortality of these animals, the test substance was
applied to the skin of the 5 remaining male rats. The animals were
observed for mortality, signs of gross toxicity, and behavioral changes
at least once daily for 14 days. Body weights were recorded prior to
application and again on Days 7 and 14 (termination). Necropsies were
performed on all animals at terminal sacrifice. All animals survived
exposure to the test substance, gained body weight, and appeared active
and healthy during the study. Apart from dermal irritation (etythema)
noted at the dose site of three female rats between Days 1 and 2, and
for two male rats on Day 1, there were no other clinical findings
recorded for any animal over the course of the study. No gross
abnormalities were noted for any of the animals when necropsied at the
conclusion of the 14-day observation period.
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