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EC number: 206-108-6
CAS number: 301-10-0
Based on the results of the 13-week study, doses of 1000 and 2000 ppm stannous chloride in feed were selected for the chronic, 105-week study.
A thirteen-week study was conducted to evaluate the cumulative toxicity
of stannous chloride and to determine the concentrations of stannous
chloride to be used in chronic studies. Male and female F344/N rats were
fed diets containing 0, 500, 1000, 1900, 3800 or 7500 ppm. Seventy to
100% of rats receiving the 3800 or 7500 ppm diets had gross distention of the cecum and reddened gastric mucosa, although no compound-related histopathologic effects were observed in the cecum, stomach, or any other tissues examined.
A NOEL of 1900 ppm (187 mg/kg bw/day) was determined based on the
effects seen at 3800 ppm.
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