Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-108-6
CAS number: 301-10-0
Acute oral LD50: 5870 mg/kg bwAcute dermal LD50: >2000 mg/kg bw
The acute oral toxicity of tin bis(2 -ethylhexanoate) was evaluated in
rats. The test material was administered without dilution at
concentrations of 1.6, 3.2, 6.4, and 12.8 g/kg, via intragastric
intubation, to four groups of 5 male rats. Animals were observed for
21-days post-exposure and mortalities were recorded daily. Animals in
the 6.4 and 12.8 g/kg dose groups were observed to be listless following
test material administration. Mortalities in these two dose groups
occurred within the first four days following test substance
administration. The single mortality in the 3.2 g/kg dose group occurred
on day 12.
The oral LD50 (+95% confidence limits) of the test substance was
reported as 5.87 (3.14-10.98) g/kg. The study was assigned a K-2 rating.
[AME Test Report]
Groups of 6 male rats were exposed to the test substance at dose levels
of 1.0, 1.7, 2.89, 4.91, and 8.35 g/kg bw. The test material was
administered in paraffin oil as a single dose by oral gavage. Animals
were observed animals for 14 days post-exposure and mortalities were
recorded. At the end of the observation period, surviving animals were
sacrificed and all animals underwent gross pathological examination. All
mortalities occurred within 1 to 2 days after dosing. Clinical signs of
toxicity included piloerection, soiled coat, hypokinesis and ataxia. No
clinical signs persisted after 11 days post-exposure. Postmortem
observations revealed fluid gut contents, pale kidneys, mottled liver,
and patchy pink lung. The oral LD50 (+95% confidence limits) of the test
substance was reported as 3.4 (2.5-4.8) g/kg bw. The study was assigned
a K-2 rating. [Dow Test Report]
An acute dermal toxicity test was conducted with Fischer 344 rats to
determine the potential for tin bis(2 -ethylhexanoate) to produce
toxicity from a single topical application. Under the conditions of this
study, the single dose acute dermal LD50 of the test substance was
greater than 2,000 mg/kg of body weight in male and female rats. Two
thousand milligrams of the test substance per kilogram of body weight
was applied to the skin of ten healthy rats for 24 hours. The animals
were observed for mortality, signs of gross toxicity, and behavioral
changes at least once daily for 14 days. Body weights were recorded
prior to application and again on Days 7 and 14 (termination).
Necropsies were performed on all animals at terminal sacrifice. All
animals survived exposure to the test substance, gained body weight, and
appeared active and healthy during the study. Apart from dermal
irritation (erythema) noted at the dose site of three female rats
between Days 1 and 2, and for two male rats on Day 1, there were no
other clinical findings recorded for any animal over the course of the
study. No gross abnormalities were noted for any of the animals when
necropsied at the conclusion of the 14-day observation period. The study
was assigned a K-1 rating. [Dow Test Report]
Studies of the acute oral toxicity of tin bis(2 -ethylhexanoate)
indicate that the material has an LD50 of 5870 mg/kg. The material is
not classified according to GHS.
Tin bis(2 -ethylhexanoate) was not toxic following single limit dose
(2000 mg/kg) dose application of the material to the skin of rats. No
GHS category was assigned for dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Damit Sie die Website optimal nutzen können, verwenden wir Cookies.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again