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EC number: 206-108-6
CAS number: 301-10-0
An approximation of the LD50 was attained by
administering the chemical compound to a number of rats on each of
several levels. A group of twenty young adult male albino rats of the
Sprague-Dawley Strain weighing approximately 200 -250 grams was selected
for use in this study. The animals were divided into four subgroups of
five animals each and fasted for twenty-four hours prior to dosing. The
experimental material was placed in a syringe and introduced through the
esophagus into the stomach with a stainless steel catheter. Five rats
were dosed at 1.6, 3.2, 6.4 and 12.8 g/kg with the test materail as
supplied. Animals on the same dosage level were then placed in a common
cage with free access to food and water. The cages employed had wire
mesh floors elevated abouve the droppings and were kept in temperature
controlled rooms at 72 deg F +/- 2 deg F. Light was furnished for eight
out of every twenty-four hour period. The animals were observed for a
twenty-one day period and deaths were recorded. The LD50 was calculated
using the Thompson Moving Average Method (Biometrics, September, 1952,
Vol. 8, No. 3). Rats which received the two higher doses were listless
following administration of compound. Fatalities occurred during the
first four days on these two levels. One death occurred on the twelfth
day at 3.2 g/kg level. The oral LD50 of tin bis(2 -ethylhexanoate) is
5.87 g/kg with 95% confidence limits of 3.14 g/kg to 10.98 g/kg.
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