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EC number: 206-108-6
CAS number: 301-10-0
An approximation of the LD50 was attained by administering the chemical
compound to a number of rats on each of several levels. Following this a
group of twenty young adult, male albino rats of the Sprague-Dawley
Strain weighing approximately 200 -250 grams was selected for use in
this study. The animals were divided into four subgroups of five animals
each and fasted for twenty-four hours prior to dosing. The experimental
material was placed in a syringe and introduced through the esophagus
into the stomach with a stainless steel catheter. Five rats were doesed
at 1.6, 3.2, 6.4 and 12.8 g/kg with the test materail as supplied.
Animals on the same dosage level were then placed in a common cage with
free access to food and water. The cages employed had wire mesh floors
elevated abouve the droppings and were kept in temperature controlled
rooms at 72 deg F +/- 2 deg F. Light was furnished for eight out of
every twenty-four hour period. The animals were observed for a
twenty-one day period and deaths were recorded. The LD50 was calculated
using the Thompson Moving Average Method (Biometrics, September, 1952,
Vol. 8, No. 3). Rats which received the two higher doses were listless
following administration of compound. Fatalities occurred during the
first four days on these two levels. One death occurred on the twelfth
day at 3.2 g/kg level. The oral LD50 of tin bis(2 -ethylhexanoate) is
5.87 g/kg with 95% confidence limits of 3.14 g/kg to 10.98 g/kg.
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