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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Very brief description of methods and results. Characterization of test material was not reported. No pathological examinations of the test animals were reported.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967
Reference Type:
publication
Title:
Final Submittal: Tin bis(2-Ethylhexanoate) CAS Number 301-10-0
Author:
The Metal Carboxylates Coalition
Year:
2007
Bibliographic source:
U.S. High Production Volume (HPV) Chemical Challenge Program

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method: The test substance was placed in a syringe and introduced through the esophagus into the stomach with a stainless steel catheter.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Tin (II) Ethylhexanoate [CAS No. 301-10-0]

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: No data
- Age at study initiation: Young adult
- Weight at study initiation: 200-250 grams
- Fasting period before study: Fasted 24 hours prior to dosing.
- Housing: Cages with wire mesh floors elevated above dropings in groups of 5.
- Diet : ad libitum
- Water : ad libitum
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature: 72 deg F
- Humidity: No data
- Air changes: No data
- Photoperiod (hrs dark / hrs light): Light was furnished for eith out of every tewnty-four hour period.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Remarks:
none
Details on oral exposure:
no vehicle
Doses:
1.6, 3.2, 6.4 and 12.8 g/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 21 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Animals were observed for 21 days.
Statistics:
The LD50 was calculated using the Thompson Moving Average Method (Biometrics, September, 1952, Vol. 8, No. 3).

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
5 870 mg/kg bw
95% CL:
>= 3.14 - <= 10.98
Remarks on result:
other: reported in g/kg
Mortality:
1.6 g/kg - 0 mortality
3.2 g/kg - one mortality on day 12 of the test
6.4 g/kg - three mortalities on day 2 of the test
12.8 g/kg - one moartality on day 2 and thee mortalities on day 4 of the test
Clinical signs:
The rats which received the two higher doses, 6.4 and 12.8 g/kg were listless following administration of the test material.
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 for tin bis(2 -ethylhexanoate) is 5.87 g/kg with 95% confidence limits of 3.14 g/kg to 10.98 g/kg.
Executive summary:

An approximation of the LD50 was attained by administering the chemical compound to a number of rats on each of several levels. Following this a group of twenty young adult, male albino rats of the Sprague-Dawley Strain weighing approximately 200 -250 grams was selected for use in this study. The animals were divided into four subgroups of five animals each and fasted for twenty-four hours prior to dosing. The experimental material was placed in a syringe and introduced through the esophagus into the stomach with a stainless steel catheter. Five rats were doesed at 1.6, 3.2, 6.4 and 12.8 g/kg with the test materail as supplied. Animals on the same dosage level were then placed in a common cage with free access to food and water. The cages employed had wire mesh floors elevated abouve the droppings and were kept in temperature controlled rooms at 72 deg F +/- 2 deg F. Light was furnished for eight out of every twenty-four hour period. The animals were observed for a twenty-one day period and deaths were recorded. The LD50 was calculated using the Thompson Moving Average Method (Biometrics, September, 1952, Vol. 8, No. 3). Rats which received the two higher doses were listless following administration of compound. Fatalities occurred during the first four days on these two levels. One death occurred on the twelfth day at 3.2 g/kg level. The oral LD50 of tin bis(2 -ethylhexanoate) is 5.87 g/kg with 95% confidence limits of 3.14 g/kg to 10.98 g/kg.