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EC number: 206-108-6
CAS number: 301-10-0
No corneal responses were observed at 1 h, but scattered or diffuse
areas of opacity (score 1) were noted in all treated eyes a t 24 h, 48 h
and 72 h. At 7 days, the response was more severe in all but one of the
treated eyes, and in one eye complete corneal opacity (score 4)
prevented observation of the iris. Very slight iridial responses were
noted in 5/6 eyes treated with stannous octoate at 1 h. The maximum
score for iridial damage (2) was recorded for 5/6 treated eyes at 24 h
and all observable irises a t 48 h, 72 h and 7 days. Positive responses
for conjunctival redness and chemosis (2 or above) and moderate or
severe discharge (score 2 or 3) were recorded in all eyes treated with
stannous octoate at all readings.
Six New Zealand White rabbits (3
male,3 female) were used in the study. Test material, at 0.1 mL, placed
into the right eye by gently pulling the lower eyelid away from the
eyeball to form a sac into which the test material was dropped. The lids
were then gently held together for 1 or 2 sec. The other eye remained
untreated to serve as a control. Instillation of 0.1 ml of the test
material into the eyes of rabbits resulted incorneal
and iridial responses to treatmentand
severe conjunctival reactions which persisted throughoutthe
test. The study was assigned a K-2 rating. Tin bis(2 -ethylhexanaote)
may be classified as a severe eye irritant in view of the corneal and
iridial responses to treatment and severe conjunctival reactions which
persisted throughout the test.
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