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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Very brief description of methods and results. Characterization of test material was not reported.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967
Reference Type:
publication
Title:
Final Submittal: Tin bis(2-Ethylhexanoate) CAS Number 301-10-0
Author:
The Metal Carboxylates Coalition
Year:
2007
Bibliographic source:
U.S. High Production Volume (HPV) Chemical Challenge Program

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Draize skin irritation technique
Deviations:
not specified
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Stannous Octoate
- Physical state: Liquid
- Lot/batch No.: No data
- Expiration date of the lot/batch: No data
- Storage condition of test material: No data
- Other:

Test animals

Species:
rabbit
Strain:
other: Albino rabbits

Test system

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
24 hour(s)
Observation period:
72 hours after application of the test material
Number of animals:
6
Details on study design:
TEST SITE
- Area of exposure: The fur was clipped from about the sixth thorasic vertebrae to the sacral region and about 4 inches from the vertebral colum on each side using an electric clipper. Two areas, approximately 10 cm apart, on the back of each rabbit were selected as application sites.
- % coverage: no data
- Type of wrap if used: Two layers of light gauze cut into squares were secured to the selected areas by strips of 1-inch wide adhesive tape.
The trunk of each rabbit was then wrapped in polyethylene sheeting and taped at both ends.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 24 hours

SCORING SYSTEM: Draize, Woodward and Calv ery as described on page 48 of "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" published by the Food and Drug Officials of the United States.

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 72 h
Score:
1.54

Any other information on results incl. tables

Mean (n=6) skin reaction scores for intact skin:
Erythema/Eschar Formation (24-h): 1.50
Edema Formation (24-h): 1.33

Erythema/Eschar Formation (72-h): 0.17
Edema Formation (72-h): 0

Mean (n=6) skin reaction scores for abraded skin:
Erythema/Eschar Formation (24-h): 1.33
Edema Formation (24-h): 1.50

Erythema/Eschar Formation (72-h): 0.17
Edema Formation (72-h): 0.17

The Primary Irritation Score was calculated to be 1.54, indicating the 

test material is mildly irritating. 

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Migrated information
Conclusions:
Utilizing a method for evaluating the skin irritation potential of an experimental material, it was found that M &T Chemicals, Inc., tin bis(2 -ethylhexanoate) is a mild irritant to intact and abraded skin of the albino rabbit.
Executive summary:

A group of six (three males and three females) healthy albino rabbits was employed in this project to study the experimental material. The fur was clipped from about the sixth thorasic vertebrae to the saral region and about 4 inches from the vertebral column on each side using an electric clipper. Two areas, approximately 10 cm apart, on the back of each rabbit were selected as application sites. One site was abraded by making four epidermal incisions in a cross hatch pattern on this site. Then 0.5 ml of the experimental material was applied to each site and patches consisting of two layers of light gauze cut into squares were secured to the selected areas by stripps of 1 inch wide adhesive tape. The trunk of each rabbit was then wrapped in polyethylene sheeting and taped at both ends. The experimental material was left in contact with the skin for 24 hours after which the trunk bands were removed and the sites examined and evaluated. The sites were again examined seventy-two hours after application. The scoring method used was Draize, Woodard and Clavary.