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EC number: 204-616-2
CAS number: 123-30-8
An oral carcinogenicity conducted in the rat was negative at doses up to 30 mg/kg/day.
4 -aminophenol is not classified as carcinogenic based on a repeated
oral oncogenicity study in rats.
4 -aminophenol was administered by daily gavage for at least 101 weeks
to Sprague-Dawley rats at 2, 5, 12 and 30 mg/kg/day. Principal effects
in this study were observed at 30 mg/kg/day and included a slightly
lower survival rate in females and orange-coloured urine which may be
due to urinary elimination of the test substance or its metabolites. The
test substance showed neither a carcinogenic potential, nor an effect on
the incidence of spontaneously occurring tumours at any dose-level.
Moreover, the test substance did not induce a decrease in the onset of
tumour appearance. Consequently, 4 -aminophenol was not considered
carcinogenic under the test conditions. This study provides weight of
evidence that the mutagenicity / clastogenicity effects observed in the
micronucleus area did not "translate" to the in vivo carcinogenicity of
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