Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information


Currently viewing:

Administrative data

Description of key information

An oral  carcinogenicity conducted in the rat was negative at doses up to 30 mg/kg/day.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Dose descriptor:
30 mg/kg bw/day

Justification for classification or non-classification

4 -aminophenol is not classified as carcinogenic based on a repeated oral oncogenicity study in rats.

Additional information

4 -aminophenol was administered by daily gavage for at least 101 weeks to Sprague-Dawley rats at 2, 5, 12 and 30 mg/kg/day. Principal effects in this study were observed at 30 mg/kg/day and included a slightly lower survival rate in females and orange-coloured urine which may be due to urinary elimination of the test substance or its metabolites. The test substance showed neither a carcinogenic potential, nor an effect on the incidence of spontaneously occurring tumours at any dose-level. Moreover, the test substance did not induce a decrease in the onset of tumour appearance. Consequently, 4 -aminophenol was not considered carcinogenic under the test conditions. This study provides weight of evidence that the mutagenicity / clastogenicity effects observed in the micronucleus area did not "translate" to the in vivo carcinogenicity of 4 -aminophenol.