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EC number: 204-616-2
CAS number: 123-30-8
Table 1. Observation of bone marrow smears (about 24 hours after
MNPCE: Micronucleated polychromatic erythrocytes
PCE: Polychromatic erythrocytes
a): Statistically significant increase from the vehicle
control value (Kastenbaum & Bowman's statistical table, P<0.05)
b): Dose-dependency by Cochran-Amitage test, P<0.01
c): Statisyically significant difference from the vehicle
control value (student's t-test, *: P<0.05; **: P<0.01)
4-aminophenol was administeed orall at doses of 125, 250 and 500 mg/kg
and at 24 hours after the administration, bone marrow smear specimens
were prepared. Sodium CMC aqueous solution of 0.5% w/v% and 1 mg/kg of
mitomycin C were used for a negative convrol and a positive control,
The occurrence frequency of immature erthrocyes having a micronucleus
increased was statistically significant in the groups administered with
the test compound compared to the negative control group and was also
dose-dependent. Additionally, the percentage of immature erythrocytes
per 200 erythrocytes was significnatly decreased in the test article
groups compared to the negative control group which was considered to be
caused by the test article causing suppressive effects at these doses on
bone marrow cell growth. The occurrence frequency of immature
erythrocytes having a micronucleus in the negtive and positive controls
was within the range of the the historical background of the laboratory,
indicating the validity of the test result.
Based on these data, 4 -aminophenol was judged capable of inducing
chromosomal aberrations in vivo in bone marrow cells of
Crlj:CD1(ICR)(SPF) strain mice under the conditions in this study.
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