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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: reports of human sensitizations
Adequacy of study:
supporting study
Study period:
2005
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review document of European Commission

Data source

Reference
Reference Type:
review article or handbook
Title:
Opinion on para-aminophenol
Author:
Scientific Committee on Consumer Products
Year:
2005
Report date:
2005

Materials and methods

Study type:
other: case reports and epidemiological studies
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-aminophenol
EC Number:
204-616-2
EC Name:
4-aminophenol
Cas Number:
123-30-8
Molecular formula:
C6H7NO
IUPAC Name:
4-aminophenol

Method

Type of population:
other: human volunteers or occupationally exposed individuals
Ethical approval:
confirmed, but no further information available
Subjects:
Various; see results below
Route of administration:
dermal

Results and discussion

Applicant's summary and conclusion

Conclusions:
These studies when taken together with the animal studies would classify 4-aminophenol as a sensitizer.