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Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data
Qualifier:
no guideline available
Principles of method if other than guideline:
No method description is provided but a standard method is likely.
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
5.48
Temp.:
25 °C
No.:
#2
pKa:
10.46
Temp.:
25 °C
Conclusions:
4- Aminophenol is amphoteric with both amine and hydroxyl functional groups; pKa values for these groups are 5.48 and 10.46, respectively. At environmental pH values from 5 to 9, the substance is expected to exist primarily as the neutral species.

Description of key information

4- Aminophenol is amphoteric with both amine and hydroxyl functional groups; pKa values for these groups are 5.48 and 10.46, respectively. At environmental pH values from 5 to 9, the substance is expected to exist primarily as the neutral species.

Key value for chemical safety assessment

pKa at 20°C:
5.48

Additional information

4- Aminophenol is amphoteric with both amine and hydroxyl functional groups; pKa values for these groups are 5.48 and 10.46, respectively. At environmental pH values from 5 to 9, the substance is expected to exist primarily as the neutral species.