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EC number: 204-616-2 | CAS number: 123-30-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 8 to May 15, 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 202 (Daphnia acute immobilisation test and reproduction test 1984
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- see below
- Vehicle:
- no
- Details on test solutions:
- see below
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- see below
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- 55.6 mg/L as CaCO3
- Test temperature:
- 20+/- C
- pH:
- 7.7
- Nominal and measured concentrations:
- Concentrations of PAP maintained between 82.5 an d 87.8 % depending on the nominal concentration.
- Details on test conditions:
- see below
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.206 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks:
- concentrations of PAP maintained between 82.5 an d 87.8 % depending on the nominal concentration
- Basis for effect:
- other: mean cumulative number of juveniles produced per adult
- Remarks on result:
- other: Values based on mean measured concentrations calculated directly from data in the study report.
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.171 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Remarks on result:
- other: 95% CL
- Details on results:
- Values based on mean measured concentrations calculated directly from data in the study report.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 at 21 days immobilization was 0.171 mg/L, the NOEC based on the mean cumulative number of juveniles produced per adult was 0.206 mg/l and the LOEC was > 0.206 mg/L.
Reference
- Measured
Concentrations: The test concentrations were measured 5 times (0, 4, 7,
14, 21st-day) using HPLC.
Nominal Conc. (mg/L) | Measured Concentration (mg/L) | ||||
0 | 4 | 7 | 14 | 21 | |
Control | --- | --- | --- | --- | --- |
0.0156 | 0.0134 | 0.0131 | 0.0138 | 0.0121 | 0.0135 |
0.0313 | 0.0263 | 0.027 | 0.028 | 0.0277 | 0.0273 |
0.0625 | 0.0539 | 0.0521 | 0.056 | 0.0566 | 0.0558 |
0.125 | 0.105 | 0.103 | 0.109 | 0.105 | 0.104 |
0.25 | 0.208 | 0.191 | 0.208 | 0.215 | 0.209 |
Nominal Conc. (mg/L) | Arithmetic Mean | % of Nominal |
Control | -- | -- |
0.0156 | 0.0132 | 84.6 |
0.0313 | 0.0273 | 87.1 |
0.0625 | 0.0549 | 87.8 |
0.125 | 0.105 | 84.2 |
0.25 | 0.206 | 82.5 |
-
Water chemistry (pH, DO, total hardness and temperature in test): Water
chemistry and temperature were measured for control and each
concentration at 0, 4, 8, 12, 17 and 21st-day.
pH: 7.1 - 7.7
DO: 8.8 - 9.0 mg/L (more than 60% of saturation)
Water Temperature: 19.9 - 20.1 C
- Cumulative Number of Died Parental Daphnia:
Measured Conc. (mg/L) | Cumulative Number of dead parental Daphnia (Percent Mortality) | ||||
0 | 4 | 7 | 14 | 21 | |
Control | 0 (0) | 0 (0) | 0 (0) | 2 (5.0) | 6 (15.0) |
0.0132 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 6 (15.0) |
0.0273 | 0 (0) | 0 (0) | 1 (2.5) | 6 (15.0) | 10 (25.0) |
0.0549 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 8 (20.0) |
0.105 | 0 (0) | 0 (0) | 7 (17.5) | 11 (27.5) | 14 (35.0) |
0.206 | 0 (0) | 1 (2.5) | 20 (50.0) | 22 (55.0) | 25 (62.5) |
-Time
(days) to First Brood Production
Control: 7 days
Concentrations: 7 - 9 days
-Cumulative numbers of juveniles produced per adult alive
Nominal Conc. (mg/L) | Measured Conc. (mg/L) | Mean Cumulative Numbers of Juveniles Produced Per Adult Alive for 21 days | ||||||||
Days | ||||||||||
0---6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | ||
Control | --- | 0---0 | 0.4 | 0.4 | 4.3 | 4.3 | 4.3 | 13.4 | 13.4 | 32.8 |
0.0156 | 0.0132 | 0---0 | 0.5 | 0.5 | 6.5 | 6.5 | 6.5 | 19.2 | 19.2 | 30.1 |
0.0313 | 0.0273 | 0---0 | 1.0 | 1.0 | 5.1 | 5.1 | 5.1 | 17 | 17 | 35.5 |
0.0625 | 0.0549 | 0---0 | 1.4 | 1.4 | 5.2 | 5.2 | 5.2 | 15.7 | 15.7 | 32 |
0.125 | 0.105 | 0---0 | 2.6 | 2.6 | 4.8 | 4.8 | 8.4 | 17.8 | 17.8 | 53 |
0.25 | 0.206 | 0---0 | 3.7 | 3.7 | 5.6 | 5.6 | 5.6 | 18.2 | 18.2 | 53.2 |
Nominal Conc. (mg/L) | Measured Conc. (mg/L) | Mean Cumulative Numbers of Juveniles Produced Per Adult Alive for 21 days | ||||||
Days | ||||||||
15 | 16 | 17 | 18 | 19 | 20 | 21 | ||
Control | -- | 32.8 | 66.6 | 66.6 | 66.6 | 97.4 | 97.4 | 124 |
0.0156 | 0.0132 | 30.1 | 65.6 | 65.6 | 65.6 | 110 | 110 | 142 |
0.0313 | 0.0273 | 35.5 | 71 | 71 | 71 | 113 | 113 | 135 |
0.0625 | 0.0549 | 32 | 74 | 74 | 74 | 105 | 105 | 128 |
0.125 | 0.105 | 53 | 108 | 108 | 108 | 158 | 158 | 182 |
0.25 | 0.206 | 53.2 | 111 | 111 | 111 | 163 | 163 | 200 |
-Cumulative
numbers of juveniles produced per adult alive for 21 days
Vessel No. | Measured Concentration* (mg/L) | |||||
Control | 0.0132 | 0.0273 | 0.0549 | 0.105 | 0.206 | |
1 | 95 | 129 | 126 | 104 | 170 | 140 |
2 | 155 | 111 | 169 | 129 | 199 | 234 |
3 | 96 | 173 | 112 | 118 | 136 | 286 |
4 | 150 | 156 | 133 | 161 | 223 | 141 |
Mean | 124 | 142 | 135 | 128 | 182 | 200 |
S.D. | 32.7 | 27.5 | 24.6 | 24.4 | 37.5 | 72.2 |
*:
Arithmetic mean of measured concentration
The average numbers of offspring in each treated groups were larger than
that of control of 124 juveniles per female.
The significant parent mortalities were observed at 0.11 and 0.21 mg/L
as 28 and 55%, respectively
Description of key information
The long-term to invertebrates key study reported a 21 day NOEC of 0.206 mg/L based on cumulative number of juveniles produced per adult.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.206 mg/L
Additional information
For long-term toxicity to invertebrates, one key experimental study in daphnia magna was reported. Daphnia Acute Immobilisation test and Reproduction test according to OECD 202 with a NOEC (21 d) of 0.206 mg/L based on cumulative number of juveniles produced per adult on freshwater invertebrates.Values based on mean measured concentrations calculated directly from data in the study report.
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