4-aminophenol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1995

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: secondary source

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

1995

Report date:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4-aminophenol

EC Number:

204-616-2

EC Name:

4-aminophenol

Cas Number:

123-30-8

Molecular formula:

C6H7NO

IUPAC Name:

4-aminophenol

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 160-220 g

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

nose/head only

Vehicle:

other: no data

Duration of exposure:

4 h

Concentrations:

3.42 mg/l

No. of animals per sex per dose:

10 animals per sex

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 3.42 mg/L air

Mortality:

All of the rats survived.

Clinical signs:

other: No effects were observed.

Gross pathology:

No effects were observed.

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU