4-aminophenol

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedures based on scientific principles and standards, limited documentation, acceptable for assessment.

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPPTS 870.1100 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

other: CFY

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 90 - 122 g
- Fasting period before study: overnight

Route of administration:

oral: gavage

Vehicle:

other: 0.5% aqueous gum tragacanth

Doses:

In a preliminary range finding study, the freshly prepared solutions or suspensions were administered to groups of two male and two female rats by oral intubation in a range of dosage volumes, in order to find the approximate median lethal oral dose (LD50). After these preliminary range-finding tests had given a rough approximation of the LD50, larger groups of rats (five males and five females) were used in order to locate the median lethal dose more precisely. A logarithmic dosage interval of 1.6 was used.

No. of animals per sex per dose:

5 animals per sex per dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

671 mg/kg bw

95% CL:

>= 550 - <= 818

CFY strain rats (5 males and 5 females) were given 4-aminophenol orally as a 0.5% aqueous tragacanth formulation. The LD50 was 671 (550 to 818) mg/kg body weight.

Interpretation of results:

Category 4 based on GHS criteria

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

671 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Dose descriptor:

LC50

Value:

3.42 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

8 000 mg/kg bw

Justification for classification or non-classification

Based on the CLP criteria, 4-aminophenol is classified as a Category 4 for acute oral toxicity, not classified for dermal toxicity and a Category 4 for acute inhalation toxicity based on the available data.