Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-616-2
CAS number: 123-30-8
The following Klimisch 1 studies have been conducted: (1) a subchronic study (90 days) conducted according to GLP and per OECD guideline in the rat with a NOAEL of 10 mg/kg bw/day and a LOAEL of 30 mg/kg bw/day and (2) a subacute toxicity study (28-day) conducted according to GLP and per OECD guideline in the rat with a NOAEL of 20 mg/kg bw/day. The NOAEL from the 90-day study was used to calculate the DNEL, long-term inhalation route systemic and DNEL, long term dermal route systemic. The primary target organ of toxicity in the 28-day study and 90-day study was the kidney.
Repeated dose toxicity: via oral route - systemic effects (target
organ) urogenital: kidneys
The subchronic 90 -day repeated dose study in the rat indicated a NOAEL
of 10 mg/kg bw/day and a LOAEL of 30 mg/kg bw/day with kidney effects
occurring at the LOAEL. Therefore, the classification of specific target
organ toxicity (STOT) repeat exposure
category 2 is supported by the data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again