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EC number: 204-616-2
CAS number: 123-30-8
Following oral administration in laboratory animals, 4
-aminophenol is well absorbed, while dermal administration in laboratory
animals is significantly less. Further data on dermal absorption for
risk assessment purposes is in the human data section. When absorbed
orally, the substance is excreted in the urine, primarily
acetamido glucuronide and acetamidophenyl glucuronide and to a lesser
extent as aminosulfate and free 4 -aminophenol. When applied dermally,
in vivo and in vitro studies in a human skin model (Episkin) indicate
that the primary metabolites are acetaminophenol
(paracetamol or APAP) and the sulfate conjugate of acetaminophenol. No
data on inhalation bioavailability or pharmacokinetics could be
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