Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Following oral administration in laboratory animals, 4 -aminophenol is well absorbed, while dermal administration in laboratory animals is significantly less. Further data on dermal absorption for risk assessment purposes is in the human data section. When absorbed orally, the substance is excreted in the urine, primarily as acetaminophenol, acetamido glucuronide and acetamidophenyl glucuronide and to a lesser extent as aminosulfate and free 4 -aminophenol. When applied dermally, in vivo and in vitro studies in a human skin model (Episkin) indicate that the primary metabolites are acetaminophenol (paracetamol or APAP) and the sulfate conjugate of acetaminophenol. No data on inhalation bioavailability or pharmacokinetics could be identified.